Regulation of tumor cell motility by ERK mitogen-activated protein kinases

被引：82

作者：

Vial, E ^{[1
]}

Pouysségur, J ^{[1
]}

机构：

[1] Ctr Antoine Lacassagne, CNRS, Inst Signaling Dev Biol & Canc, UMR 6543, F-06189 Nice, France

来源：

SIGNAL TRANSDUCTION PATHWAYS, CHROMATIN STRUCTURE, AND GENE EXPRESSION MECHANISMS AS THERAPEUTIC TARGETS | 2004年 / 1030卷

关键词：

ERK MAPK; cell motility; metastasis; cell adhesion; Rho GTPases;

D O I：

10.1196/annals.1329.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis is the main cause of human cancer deaths, and cell motility is one key component of the process of metastasis. The ERK mitogen-activated protein kinase (MAPK) signaling pathway is probably one of the most commonly activated in malignant human cancers. We describe the molecular mechanisms by which ERK MAPK signaling regulates cell motility and its importance for cancer cell dissemination.

引用

页码：208 / 218

页数：11

共 73 条

[11] Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration [J].

Cary, LA ;

Han, DC ;

Polte, TR ;

Hanks, SK ;

Guan, JL .

JOURNAL OF CELL BIOLOGY, 1998, 140 (01) :211-221

[12] A fluorescent resonant energy transfer-based biosensor reveals transient and regional myosin light chain kinase activation in lamella and cleavage furrows [J].

Chew, TL ;

Wolf, WA ;

Gallagher, PJ ;

Matsumura, F ;

Chisholm, RL .

JOURNAL OF CELL BIOLOGY, 2002, 156 (03) :543-553

[13] Imaging of cancer invasion and metastasis using green fluorescent protein [J].

Condeelis, JS ;

Wyckoff, J ;

Segall, JE .

EUROPEAN JOURNAL OF CANCER, 2000, 36 (13) :1671-1680

[14] Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases [J].

Cox, EA ;

Sastry, SK ;

Huttenlocher, A .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (02) :265-277

[15] Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[16] Ras signalling and apoptosis [J].

Downward, J .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (01) :49-54

[17]

Ellenrieder V, 2001, CANCER RES, V61, P4222

[18] Identification of a novel inhibitor of mitogen-activated protein kinase kinase [J].

Favata, MF ;

Horiuchi, KY ;

Manos, EJ ;

Daulerio, AJ ;

Stradley, DA ;

Feeser, WS ;

Van Dyk, DE ;

Pitts, WJ ;

Earl, RA ;

Hobbs, F ;

Copeland, RA ;

Magolda, RL ;

Scherle, PA ;

Trzaskos, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) :18623-18632

[19] Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src [J].

Fincham, VJ ;

James, M ;

Frame, MC ;

Winder, SJ .

EMBO JOURNAL, 2000, 19 (12) :2911-2923

[20] The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility [J].

Fincham, VJ ;

Frame, MC .

EMBO JOURNAL, 1998, 17 (01) :81-92

← 1 2 3 4 5 6 7 8 →