Regulation of tumor cell motility by ERK mitogen-activated protein kinases

被引：82

作者：

Vial, E ^{[1
]}

Pouysségur, J ^{[1
]}

机构：

[1] Ctr Antoine Lacassagne, CNRS, Inst Signaling Dev Biol & Canc, UMR 6543, F-06189 Nice, France

来源：

SIGNAL TRANSDUCTION PATHWAYS, CHROMATIN STRUCTURE, AND GENE EXPRESSION MECHANISMS AS THERAPEUTIC TARGETS | 2004年 / 1030卷

关键词：

ERK MAPK; cell motility; metastasis; cell adhesion; Rho GTPases;

D O I：

10.1196/annals.1329.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis is the main cause of human cancer deaths, and cell motility is one key component of the process of metastasis. The ERK mitogen-activated protein kinase (MAPK) signaling pathway is probably one of the most commonly activated in malignant human cancers. We describe the molecular mechanisms by which ERK MAPK signaling regulates cell motility and its importance for cancer cell dissemination.

引用

页码：208 / 218

页数：11

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