Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum

被引：11
|
作者：
Song, Chenggang [1 ]
Ding, Gang [2 ]
Wu, Gang [1 ]
Yang, Jian [3 ]
Zhang, Mingzhe [1 ]
Wang, Haoyu [1 ]
Wei, Dongsheng [4 ]
Qin, Jianchun [1 ]
Guo, Lanping [3 ]
机构：
[1] Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100193, Peoples R China
[3] China Acad Chinese Med Sci, Natl Resources Ctr Chinese Mat Med, State Key Lab Dao Di Herbs Breeding Base, Beijing 100700, Peoples R China
[4] Univ Hamburg, Inst Wood Sci, Dept Biol, Leuschnerstr 91, D-21031 Hamburg, Germany
来源：
CHEMISTRY & BIODIVERSITY | 2020年 / 17卷 / 03期
基金：
中国国家自然科学基金;
关键词：
azaphilone; Chaetomium globosum; Polygonatum sibiricum; structure identification; cytotoxicity; ABSOLUTE STEREOSTRUCTURES; CYTOTOXIC METABOLITES; CHAETOGLOBOSIN; CHAETOMUGILINS; ALKALOIDS; FUNGUS;
D O I：
10.1002/cbdv.201900744
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new azaphilone, chaephilone E, eight azaphilone derivatives, and three chaetoglobosins were isolated from endophytic fungi Chaetomium globosum. The structures of the compounds were elucidated by 1D and 2D NMR as well as HR-ESI-MS data, and the absolute configuration of chaephilone E was established on the basis of electronic circular dichroism and NOESY spectrum. The activity of chaephilone E was evaluated via the cytotoxic assay (human hepatoma cell lines HepG-2) and brine shrimp (Artemia salina) bioassay.
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页数：5
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