The Utility of the Platelet-Lymphocyte Ratio for Predicting No Reflow in Patients With ST-Segment Elevation Myocardial Infarction

被引：64
作者：
Yildiz, Abdulkadir [1 ]
Yuksel, Murat [1 ]
Oylumlu, Mustafa [1 ]
Polat, Nihat [1 ]
Akyuz, Abdurrahman [1 ]
Acet, Halit [1 ]
Aydin, Mesut [1 ]
Ulgen, Mehmet Siddik [1 ]
机构：
[1] Dicle Univ, Dept Cardiol, Sch Med, Diyarbakir, Turkey
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2015年 / 21卷 / 03期
关键词：
primary percutaneous coronary intervention; acute ST-segment elevation myocardial infarction; platelet to lymphocyte ratio; no reflow; PERCUTANEOUS CORONARY INTERVENTION; C-REACTIVE PROTEIN; NEUTROPHIL/LYMPHOCYTE RATIO; NEUTROPHIL; IMPACT; ANGIOPLASTY; ASSOCIATION; MORTALITY; SEVERITY; DISEASE;
D O I：
10.1177/1076029613519851
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of the study was to evaluate the utility of the preprocedural platelet-lymphocyte ratio (PLR) for predicting no reflow in patients undergoing primary percutaneous intervention (PCI) for the treatment of ST-segment elevation myocardial infarction. The thrombolysis in myocardial infarction (TIMI) flow grades of 287 patients treated with primary PCI were assessed retrospectively. Patients were divided into 3 tertiles based upon preprocedural PLR. Pre- and postprocedural TIMI flow grades were evaluated. No reflow developed in 6, 14, and 43 patients in the lower, middle, and higher tertiles, respectively (P < .001). After multivariate analysis, PLR remained a significant predictor of no reflow together with neutrophil-lymphocyte ratio (NLR). A cutoff value of 160 for PLR and 5.9 for NLR predicted no reflow with sensitivities and specificities of 75% and 71% and 74% and 70%, respectively. In conclusion, high preprocedural PLR and NLR levels are significant and independent predictors of no reflow in patients undergoing primary PCI.
引用
收藏
页码：223 / 228
页数：6
相关论文
共 36 条
[1]  
Acar G, 2013, CLIN APPL THROMB HEM
[2]   Relation of Neutrophil/Lymphocyte Ratio to Coronary Flow to In-Hospital Major Adverse Cardiac Events in Patients With ST-Elevated Myocardial Infarction Undergoing Primary Coronary Intervention [J].
Akpek, Mahmut ;
Kaya, Mehmet Gungor ;
Lam, Yat Yin ;
Sahin, Omer ;
Elcik, Deniz ;
Celik, Turgay ;
Ergin, Ali ;
Gibson, Charles Michael .
AMERICAN JOURNAL OF CARDIOLOGY, 2012, 110 (05) :621-627
[3]  
[Anonymous], ANGIOLOGY
[4]   Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography [J].
Arbel, Yaron ;
Finkelstein, Ariel ;
Halkin, Amir ;
Birati, Edo Y. ;
Revivo, Miri ;
Zuzut, Meital ;
Shevach, Ayala ;
Berliner, Shlomo ;
Herz, Itzhak ;
Keren, Gad ;
Banai, Shmuel .
ATHEROSCLEROSIS, 2012, 225 (02) :456-460
[5]   Monocyte heterogeneity in myocardial infarction with and without ST elevation and its association with angiographic findings [J].
Arslan, Ugur ;
Kocaoglu, Ibrahim ;
Balci, Mustafa M. ;
Gulkan, Birsen ;
Falay, Mesude Y. ;
Temizhan, Ahmet .
CORONARY ARTERY DISEASE, 2013, 24 (05) :404-411
[6]   Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction [J].
Azab, Basem ;
Shah, Neeraj ;
Akerman, Meredith ;
McGinn, Joseph T., Jr. .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2012, 34 (03) :326-334
[7]   Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction [J].
Bolognese, L ;
Carrabba, N ;
Parodi, G ;
Santoro, GM ;
Buonamici, P ;
Cerisano, G ;
Antoniucci, D .
CIRCULATION, 2004, 109 (09) :1121-1126
[8]  
Celik T, 2013, ANGIOLOGY
[9]   The impact of admission C-reactive protein levels on the development of no-reflow phenomenon after primary PCI in patients with acute myocardial infarction: The role of inflammation [J].
Celik, Turgay ;
Iyisoy, Atila ;
Yuksel, U. Cagdas ;
Jata, Bekim ;
Ozkan, Mustafa .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 136 (01) :86-88
[10]  
Gul M, 2012, CLIN APPL THROMB HEM
1234