Efficacy of Dupilumab on Different Phenotypes of Adult with Moderate-to-Severe Atopic Dermatitis in Taiwan: A Real-World Study

被引：3

作者：

Yang, Chin-Yi ^{[1
,2
,3
,4
]}

Lai, Po-Ju ^{[5
,6
]}

Chen, Chun-Bing ^{[2
,3
,4
,7
,8
,9
,10
,11
]}

Chan, Tom C. ^{[12
,13
]}

Hui, Rosaline Chung-Yee ^{[2
,3
,4
,7
,8
,9
,14
]}

Huang, Yu-Huei ^{[2
,3
,4
,6
]}

Tseng, Han-Chi ^{[3
,15
,16
]}

Lin, Shang-Hung ^{[3
,15
,16
]}

Lu, Chun-Wei ^{[2
,3
,4
,7
,8
,9
]}

Lee, Hua-En ^{[2
,3
]}

Lin, Jing-Yi ^{[2
,3
,4
]}

Chi, Min-Hui ^{[2
,3
,4
,7
,13
,17
]}

Tsai, Ming-Feng ^{[18
,19
,20
]}

Hwang, Yih-Shiou ^{[3
,21
,22
,23
]}

Wang, Chuang-Wei ^{[2
,3
,4
,7
,8
,9
]}

Chu, Chia-Yu ^{[12
,13
]}

Chung, Wen-Hung ^{[2
,3
,4
,7
,8
,9
,10
]}

机构：

[1] New Taipei Municipal TuCheng Hosp, Dept Dermatol, New Taipei 236, Taiwan

[2] Linkou Chang Gung Mem Hosp, Drug Hypersensit Clin & Res Ctr, Dept Dermatol, Taoyuan 333, Taiwan

[3] Chang Gung Univ, Coll Med, Sch Med, Taoyuan 333, Taiwan

[4] Linkou Chang Gung Mem Hosp, Chang Gung Immunol Consortium, Taoyuan 333, Taiwan

[5] Chung Shan Med Univ Hosp, Dept Dermatol, Taichung 402, Taiwan

[6] Chung Shan Med Univ, Inst Med, Taichung 402, Taiwan

[7] Keelung Chang Gung Mem Hosp, Whole Genome Res Core Lab Human Dis, Keelung 204, Taiwan

[8] Linkou Chang Gung Mem Hosp, Genom Med Core Lab, Taoyuan 333, Taiwan

[9] Linkou Chang Gung Mem Hosp, Immune Oncol Ctr Excellence, Taoyuan 333, Taiwan

[10] Xiamen Chang Gung Hosp, Dept Dermatol, Xiamen 361028, Peoples R China

[11] Natl Tsing Hua Univ, Sch Med, Hsinchu 300044, Taiwan

[12] Natl Taiwan Univ Hosp, Dept Dermatol, Taipei 100, Taiwan

[13] Natl Taiwan Univ, Dept Dermatol, Coll Med, Taipei 100, Taiwan

[14] Keelung Chang Gung Mem Hosp, Drug Hypersensit Clin & Res Ctr, Dept Dermatol, Keelung 204, Taiwan

[15] Kaohsiung Chang Gung Mem Hosp, Dept Dermatol, Kaohsiung 833, Taiwan

[16] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Taoyuan 333, Taiwan

[17] Natl Taiwan Univ, Coll Med, Inst Mol Med, Taipei 106, Taiwan

[18] Mackay Mem Hosp, Dept Surg, Div Plast Surg, Taipei 104, Taiwan

[19] MacKay Med Coll, Dept Med, New Taipei 252, Taiwan

[20] Taipei Med Univ, Grad Inst Biomed Informat, Coll Med Sci & Technol, Taipei 110, Taiwan

[21] Linkou Chang Gung Mem Hosp, Linkou Med Ctr, Dept Ophthalmol, Taoyuan 333, Taiwan

[22] Jen Ai Hosp, Dept Ophthalmol, Dali Branch, Taichung 412, Taiwan

[23] Xiamen Chang Gung Mem Hosp, Dept Ophthalmol, Xiamen 361028, Peoples R China

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 20期

关键词：

atopic dermatitis; biomarker; dupilumab; eczema phenotype; efficacy; MANAGEMENT; FEATURES; PLACEBO;

D O I：

10.3390/jcm11206209

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine phenotype-related dupilumab response in adult patients with atopic dermatitis (AD), this multicenter, retrospective study included 111 adults with moderate-to-severe AD in Taiwan, with median age of 31.5 years (18-87) and 71 (64.0%) males. Patients received dupilumab 300 mg per two to three weeks up to 12 months. We found a significant improvement after 4 and 16 weeks of treatment in all patients for all the assessed scores, including eczema area and severity index (EASI) improvement >= 50% (EASI-50) and 75% (EASI-75), EASI reaching minimal clinically important difference (MCID), and Investigator's Global Assessment (IGA) improvement >= 2. Importantly, prior to asthma, early AD onset and 3-week drug intervals were significantly associated with a high proportion of EASI-75 at month 12, while prurigo and lichenoid phenotypes were associated with a lower proportion of EASI-75 at month 12. However, the majority of adverse events were mild in severity. In conclusion, our study results identify phenotype-related dupilumab response at month 12 in adults with moderate-to-severe AD, and we suggest that treatment should not be discontinued until reaching a satisfactory clinical response.

引用

页数：15

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