Development, characterization and antimicrobial properties of silver nanoparticles loaded chitosan-alginate sponges for biomedical application

被引：6

作者：

Yanovska, A. ^{[1
]}

Husak, Ye ^{[1
]}

Korniienko, V ^{[1
]}

Holubnycha, V ^{[1
]}

Mishchenko, O. ^{[2
]}

Banasiuk, R. ^{[3
,5
]}

Radwan-Praglowska, J. ^{[4
]}

Piatkowski, M. ^{[4
]}

Janus, L. ^{[4
]}

Pogorielov, M. ^{[1
,2
]}

机构：

[1] Sumy State Univ, 2 Rymskogo Korsakova Str, UA-40007 Sumy, Ukraine

[2] NanoPrime, Metalowcow 23, PL-39200 Debica, Poland

[3] NanoWave, Warsaw, Poland

[4] Cracow Univ Technol, Fac Chem Engn & Technol, Warszawska 24 Str, PL-31155 Krakow, Poland

[5] Gdansk Univ Technol, Mech Fac, G Narutowicza 11-12, PL-80233 Gdansk, Poland

来源：

JOURNAL OF MATERIALS RESEARCH | 2021年 / 36卷 / 16期

基金：

欧盟地平线“2020”;

关键词：

Biomaterial; Composite; Ag; Degradable; Membrane; Nanostructure; IN-VITRO; ANTIBACTERIAL ACTIVITY; NANOFIBERS; STABILITY; MEMBRANES; BACTERIA; SCAFFOLD;

D O I：

10.1557/s43578-021-00358-4

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this study chitosan/alginate (Ch/Alg) composite scaffolds were prepared using a freeze-drying method and loaded with various concentrations of silver nanoparticles (AgNPs). Structural, chemichal composition as well as biocompatibility and antibacterial properties were studied focused to biomedical application. Formation of polyelectrolyte complexes between chitosan and sodium alginate increases the mechanical resistance of the scaffold as well as porous morphology of the sample which is crucial for cell culture applications and results in the formation of a material characterized by good structural integrity. As-cast materials demonstrate high biocompatibility profile but AgNPs-loaded scaffold demonstrate minor cell inhibitory potencial. The early silver ion release during material degradation can affect cell viability, cell adhesion and proliferation. AgNPs in concentration of 6 x 10(-5) g/mL significantly improves the antibacterial effect of sponges Alg/Ch/NaHCO3 (2:2:1), Alg/Ch/NaHCO3 (1:3:1) and Ch/NaHCO3 (1:1) against Gram-negative bacteria.

引用

页码：3267 / 3277

页数：11

共 33 条

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