Elevated Myostatin Levels in Patients with Liver Disease: A Potential Contributor to Skeletal Muscle Wasting

被引：82

作者：

Garcia, Paul S. ^{[1
]}

Cabbabe, Amy ^{[1
]}

Kambadur, Ravi ^{[2
]}

Nicholas, Gina ^{[3
]}

Csete, Marie ^{[1
,4
]}

机构：

[1] Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USA

[2] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore

[3] AgResearch, Hamilton, New Zealand

[4] Organovo Inc, Res & Dev, San Diego, CA 92121 USA

来源：

ANESTHESIA AND ANALGESIA | 2010年 / 111卷 / 03期

关键词：

BONE-MINERAL DENSITY; HYPERTROPHY; MICE;

D O I：

10.1213/ANE.0b013e3181eac1c9

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Loss of skeletal muscle mass is a poorly understood complication of end-stage liver disease (ESLD). Based on recent stem cell literature, we hypothesized that the potent negative regulator of muscle mass, myostatin, could play a role in the muscle loss associated with ESLD. In this preliminary investigation, we measured myostatin levels in patients undergoing liver transplant evaluation, using a novel enzyme-linked immunosensitivity assay. Myostatin levels were significantly elevated in patients with ESLD compared with healthy controls. These data suggest that myostatin deserves further investigation as a target for therapies designed to preserve muscle mass in patients with ESLD. (Anesth Analg 2010;111:707-9)

引用

页码：707 / 709

页数：3

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