Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1

被引：136

作者：

Takatsuna, H

Asagiri, M

Kubota, T

Oka, K

Osada, T

Sugiyama, C

Saito, H

Aoki, K

Ohya, K

Takayanagi, H

Umezawa, K

机构：

[1] Keio Univ, Dept Appl Chem, Fac Sci & Technol, Kohoku Ku, Yokohama, Kanagawa 2230061, Japan

[2] Tokyo Med & Dent Univ, Dept Cellular Physiol Chem, Grad Sch, Tokyo, Japan

[3] Tokyo Med & Dent Univ, COE Program Frontier Res Mol Destruct & Reconstru, Grad Sch, Tokyo, Japan

[4] Keio Univ, Dept Biosci & Infomat, Fac Sci & Technol, Yokohama, Kanagawa 223, Japan

[5] Tokyo Med & Dent Univ, Dept Hard Tissue Engn, Grad Sch, Tokyo, Japan

[6] Japan Sci & Technol Agcy, Solut Oriented Res Sci & Technol, Kawaghuchi, Japan

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 04期

关键词：

NF-kappa B; RANKL; NFATc1; osteoclastogenesis; bone resorption;

D O I：

10.1359/JBMR.041213

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

(-)-DHMEQ, a newly designed NF-kappa B inhibitor, inhibited RANKL-induced osteoclast differentiation in mouse BMMs through downregulation of the induction of NFATc1, an essential transcription factor of osteoclastogenesis.

引用

页码：653 / 662

页数：10

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