A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

被引：17
|
作者：
Wu, Luling [1 ]
Tian, Xue [1 ]
Han, Hai-Hao [2 ]
Wang, Jie [2 ]
Groleau, Robin R. [1 ]
Tosuwan, Paramabhorn [3 ]
Wannalerse, Boontana [3 ]
Sedgwick, Adam C. [4 ]
Bull, Steven D. [1 ]
He, Xiao-Peng [2 ]
James, Tony D. [1 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] East China Univ Sci & Technol, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China
[3] Kasetsart Univ, Facultry Sci, Dept Chem, Bangkok 10900, Thailand
[4] Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Autin, TX 78712 USA
来源：
CHEMISTRYOPEN | 2019年 / 8卷 / 12期
基金：
中国国家自然科学基金; 英国工程与自然科学研究理事会;
关键词：
near-infrared; fluorescence; boronate; peroxynitrite; probe; OXIDATIVE STRESS; FREE-RADICALS; IN-VIVO; SENSOR; HEALTH;
D O I：
10.1002/open.201900301
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of peroxynitrite (ONOO-). DCM-Bpin exhibits selective fluorescence off-on response for ONOO- over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO- in HeLa cells.
引用
收藏
页码：1407 / 1409
页数：3
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