A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

被引：17

作者：

Wu, Luling ^{[1
]}

Tian, Xue ^{[1
]}

Han, Hai-Hao ^{[2
]}

Wang, Jie ^{[2
]}

Groleau, Robin R. ^{[1
]}

Tosuwan, Paramabhorn ^{[3
]}

Wannalerse, Boontana ^{[3
]}

Sedgwick, Adam C. ^{[4
]}

Bull, Steven D. ^{[1
]}

He, Xiao-Peng ^{[2
]}

James, Tony D. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] East China Univ Sci & Technol, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

[3] Kasetsart Univ, Facultry Sci, Dept Chem, Bangkok 10900, Thailand

[4] Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Autin, TX 78712 USA

来源：

CHEMISTRYOPEN | 2019年 / 8卷 / 12期

基金：

英国工程与自然科学研究理事会; 中国国家自然科学基金;

关键词：

near-infrared; fluorescence; boronate; peroxynitrite; probe; OXIDATIVE STRESS; FREE-RADICALS; IN-VIVO; SENSOR; HEALTH;

D O I：

10.1002/open.201900301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of peroxynitrite (ONOO-). DCM-Bpin exhibits selective fluorescence off-on response for ONOO- over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO- in HeLa cells.

引用

页码：1407 / 1409

页数：3

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