Serum oxidative - antioxidative status in patients with ankylosing spondilitis

被引:61
作者
Karakoc, Mehmet
Altindag, Ozlem [1 ]
Keles, Huseyin
Soran, Neslihan
Selek, Sahabettin
机构
[1] Harran Univ, Fac Med, Res Hosp, Dept Phys Med & Rehabil, TR-63100 Sanliurfa, Turkey
[2] Ozel Yasam Hosp, Dept Phys Med & Rehabil, Aksaray, Turkey
[3] Harran Univ, Fac Med, Dept Biochem, TR-63100 Sanliurfa, Turkey
关键词
ankylosing spondylitis; oxidative stress; antioxidants; spondyloarthropathies;
D O I
10.1007/s00296-007-0352-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ankylosing spondylitis ( AS) is an in flammatory disorder with unknown etiology that mainly affects the axial skeleton as well as the peripheral joints and extra-articular structures. The aim of this study was to evaluate the total antioxidant status (TAS), total oxidative status (TOS) and oxidative stress index (OSI) in patients with ankylosing spondylitis ( AS). Fifty AS patients with a mean Bath AS Activity Index (BASDAI) 4.6 ( range 4-9.3) and 26 healthy controls were included in the study. Plasma TAS, TOS levels were determined by using novel automated methods. The OSI was calculated. Plasma TOS level and OSI values were significantly higher, and plasma TAS level was lower in patients than in healthy controls ( 15.8 +/- 4. 9 vs. 4.3 +/- 2.8, 12.8 +/- 3. 9 vs. 9.6 +/- 5.5, 1.2 +/- 0.03 vs. 1.8 +/- 0.2, respectively, P < 0.001 for all). There was no significant correlation between oxidant/antioxidant parameters and disease activity. The results of this study indicated that increased oxidant and decreased antioxidant capacity may be associated with the pathogenesis of AS.
引用
收藏
页码:1131 / 1134
页数:4
相关论文
共 21 条
[1]  
BIASI D, 1995, CLIN EXP RHEUMATOL, V13, P623
[2]   HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT [J].
BLAKE, DR ;
MERRY, P ;
UNSWORTH, J ;
KIDD, BL ;
OUTHWAITE, JM ;
BALLARD, R ;
MORRIS, CJ ;
GRAY, L ;
LUNEC, J .
LANCET, 1989, 1 (8633) :289-293
[3]   Defining disease activity in ankylosing spondylitis: is a combination of variables (Bath Ankylosing Spondylitis Disease Activity Index) an appropriate instrument? [J].
Calin, A ;
Nakache, JP ;
Gueguen, A ;
Zeidler, H ;
Mielants, H ;
Dougados, M .
RHEUMATOLOGY, 1999, 38 (09) :878-882
[4]   A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation [J].
Erel, O .
CLINICAL BIOCHEMISTRY, 2004, 37 (04) :277-285
[5]   A new automated colorimetric method for measuring total oxidant status [J].
Erel, O .
CLINICAL BIOCHEMISTRY, 2005, 38 (12) :1103-1111
[6]   ROS as signalling molecules in T cells - evidence for abnormal redox signalling in the autoimmune disease, rheumatoid arthritis [J].
Griffiths, HR .
REDOX REPORT, 2005, 10 (06) :273-280
[7]  
Harma M, 2003, SWISS MED WKLY, V133, P563
[8]   The role of reactive oxygen species in homeostasis and degradation of cartilage [J].
Henrotin, YE ;
Bruckner, P ;
Pujol, JPL .
OSTEOARTHRITIS AND CARTILAGE, 2003, 11 (10) :747-755
[9]   Oxidation in rheumatoid arthritis [J].
Hitchon, CA ;
El-Gabalawy, HS .
ARTHRITIS RESEARCH & THERAPY, 2004, 6 (06) :265-278
[10]   The oxidative metabolism of circulating phagocytes in ankylosing spondylitis: determination by whole blood chemiluminescence [J].
Ho, KJ ;
Chen, PQ ;
Chang, CY ;
Lu, FJ .
ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 (05) :338-341