β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

被引：146
作者：
Dai, Jiangkun [1 ]
Dan, Wenjia [1 ]
Schneider, Uwe [2 ]
Wang, Junru [1 ]
机构：
[1] Northwest A&F Univ, Coll Chem & Pharm, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
[2] Univ Edinburgh, EaStCHEM Sch Chem, Kings Bldg,David Brewster Rd, Edinburgh EH9 3FJ, Midlothian, Scotland
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 157卷
基金：
中国国家自然科学基金;
关键词：
beta-Carboline; Monomer; Dimer; Occurrence; Structural diversity; Biological activity; SAR; Mechanism; TUNICATE EUDISTOMA-OLIVACEUM; PICRASMA-QUASSIOIDES BENNET; SPONGE ACANTHOSTRONGYLOPHORA-INGENS; NONREARRANGED MONOTERPENOID UNIT; TROPICAL PARASITIC DISEASES; POTENTIAL ANTITUMOR AGENTS; 2 CANTHIN-6-ONE ALKALOIDS; PICTET-SPENGLER REACTION; SIMPLE INDOLE ALKALOIDS; MANZAMINE ALKALOIDS;
D O I：
10.1016/j.ejmech.2018.08.027
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
beta-Carboline alkaloids are a family of natural and synthetic products with great structural diversity and outstanding biological activities. This review covers critically important developments in the field of beta-carbolines, predominantly over the past decade (2006-2017.7). It is focused on both natural and synthetic monomers as well as dimers, and includes key information on occurrence, structural diversity, and biological activities. In the cases where sufficient information is available, structure activity relationship (SAR) and mechanism of their biological activities were presented. In addition, innovative syntheses of the beta-carboline core and potential future directions have been discussed. (C) 2018 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：622 / 656
页数：35
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