miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer

被引：0

作者：

Liu, Hui ^{[1
]}

Xiang, Yuan ^{[1
,2
]}

Zong, Qi-Bei ^{[1
]}

Zhang, Xiao-Yu ^{[1
]}

Wang, Zhi-Wen ^{[3
]}

Fang, Shi-Qiang ^{[2
]}

Zhang, Tong-Cun ^{[1
]}

Liao, Xing-Hua ^{[1
]}

机构：

[1] Wuhan Univ Sci & Technol, Coll Life & Hlth Sci, Inst Biol & Med, Wuhan 430081, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Med Lab, Wuhan 430014, Hubei, Peoples R China

[3] Yueyang Vocat & Tech Coll, Yueyang Key Lab Chron Noncommunicable Dis, Yueyang 414000, Hunan, Peoples R China

来源：

AGING-US | 2021年 / 13卷 / 21期

基金：

中国国家自然科学基金;

关键词：

TIMP1; miR-6745; oncogenesis; Wnt/beta-catenin pathway; gastric cancer; TIMP1; PROGNOSIS; VARIANTS;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tissue inhibitor matrix metalloproteinase 1 (TIMP1) has been reported to act as a tumor oncogene in colon cancer. However, little is known about the biological role of TIMP1 in gastric cancer. In this study, we found that the expression of TIMP1 in GC tissues was upregulated compared with the normal gastric tissues. TIMP1 was confirmed as a direct target of miR-6745 and silencing TIMP1 mimicked the effects of miR-6745 in GC cells. Further mechanism studies have shown that miR-6745 inhibits the Wnt/beta-catenin pathway by targeting TIMP1, thereby inhibiting cell proliferation, migration and invasion. In addition, through the analysis of GC tissues, negative correlation between miR-6745 and TIMP1 was found in 42 GC tissues. Our findings indicate that the miR-6745-TIMP1 axis regulates Wnt/beta catenin signaling and participates in GC tumorigenesis and provide potential therapeutic target for preventing GC progression.

引用

页码：24402 / 24416

页数：15

共 36 条

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