4-Alkyl-3-azidomethyl-2-ethoxy-2,5-dihydro-5H-1,2-oxaphosphole 2-Oxides: Synthesis and 1,3-Cycloaddition

被引：1

作者：

Brel, Valery K. ^{[1
]}

Alekseychuk, Ekaterina P. ^{[1
]}

Artyushin, Oleg I. ^{[1
]}

Anikina, Lada V. ^{[1
]}

机构：

[1] Russian Acad Sci, Nesmeyanov Inst Organoelement Cpds, Str Vavilova 28, Moscow 119991, Russia

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 07期

关键词：

allenes; azides; 1,2-oxaphosphole 2-oxides; 1,2,3-triazoles; indolylglyoxyl derivatives; MICROTUBULE INHIBITOR; IN-VIVO; BUTENOLIDE; CYCLOPHOSPHAMIDE; DERIVATIVES; CYCLIZATION; MECHANISMS; BINDING; CELLS; ACID;

D O I：

10.1055/s-0040-1720922

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from phosphorylated allenes, a three-steps synthesis of a new class of organic azides with a 1,2-oxaphospholene carbon skeleton has been developed. The series of obtained 4-alkyl-3-azidomethyl-2-ethoxy-2,5-dihydro-5 H -1,2-oxaphosphole 2-oxides were utilized in the 1,3-cycloaddition with alkyl 2-[1-(propyn-2-yl)-1 H -indol-3-yl]-2-oxoacetates for the synthesis of conjugates, which are potentially active cytostatics.

引用

页码：1823 / 1832

页数：10

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