Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes

被引：3

作者：

Viebig, NK

Andrews, KT

van Kooyk, Y

Lanzer, M

Knolle, PA

机构：

[1] Univ Bonn, Inst Mol Med & Expt Immunol, D-53105 Bonn, Germany

[2] Univ Heidelberg, Abt Parasitol, Inst Hyg, D-69120 Heidelberg, Germany

[3] Zentrum Mol Biol Heidelberg, D-69120 Heidelberg, Germany

[4] Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Mol Cell Biol, NL-1081 Amsterdam, Netherlands

来源：

PARASITOLOGY RESEARCH | 2005年 / 96卷 / 04期

关键词：

L-SIGN; DC-SIGN; Plasmodium falciparum; cytoadhesion; malaria;

D O I：

10.1007/s00436-005-1360-4

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.

引用

页码：247 / 252

页数：6

共 38 条

[1] THE PATHOLOGY OF HUMAN CEREBRAL MALARIA
AIKAWA, M
ISEKI, M
BARNWELL, JW
TAYLOR, D
OO, MM
HOWARD, RJ
[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1990, 43 (02) : 30 - 37
[2] Recovery of adhesion to chondroitin-4-sulphate in Plasmodium falciparum varCSA disruption mutants by antigenically similar PfEMP1 variants
Andrews, KT
Pirrit, LA
Przyborski, JM
Sanchez, CP
Sterkers, Y
Ricken, S
Wickert, H
Lépolard, C
Avril, M
Scherf, A
Gysin, R
Lanzer, M
[J]. MOLECULAR MICROBIOLOGY, 2003, 49 (03) : 655 - 669
[3] A human schwannoma cell line supports the in vitro adhesion of Plasmodium falciparum infected erythrocytes to chondroitin-4-sulfate
Andrews, KT
Viebig, NK
Wissing, F
Klatt, N
Oster, N
Wickert, H
Knolle, P
Lanzer, M
[J]. PARASITOLOGY RESEARCH, 2003, 89 (03) : 188 - 193
[4] CLONING THE PLASMODIUM-FALCIPARUM GENE ENCODING PFEMP1, A MALARIAL VARIANT ANTIGEN AND ADHERENCE RECEPTOR ON THE SURFACE OF PARASITIZED HUMAN ERYTHROCYTES
BARUCH, DI
PASLOSKE, BL
SINGH, HB
BI, XH
MA, XC
FELDMAN, M
TARASCHI, TF
HOWARD, RJ
[J]. CELL, 1995, 82 (01) : 77 - 87
[5] A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
Bashirova, AA
Geijtenbeek, TBH
van Duijnhoven, GCF
van Vliet, SJ
Eilering, JBG
Martin, MP
Wu, L
Martin, TD
Viebig, N
Knolle, PA
KewalRamani, VN
van Kooyk, Y
Carrington, M
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (06) : 671 - 678
[6] BERENDT AR, 1994, PARASITOLOGY, V108, P19
[7] Endothelial cell-mediated uptake of a hepatitis B virus: A new concept of liver targeting of hepatotropic microorganisms
Breiner, KM
Schaller, H
Knolle, PA
[J]. HEPATOLOGY, 2001, 34 (04) : 803 - 808
[8] L-SIGN (CD209L) and DC-SIGN (0209) mediate transinfection of liver cells by hepatitis C virus
Cormier, EG
Durso, RJ
Tsamis, F
Boussemart, L
Manix, C
Olson, WC
Gardner, JP
Dragic, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (39) : 14067 - 14072
[9] Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion
Craig, A
Scherf, A
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 115 (02) : 129 - 143
[10] The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
Engering, A
Geijtenbeek, TBH
van Vliet, SJ
Wijers, M
van Liempt, E
Demaurex, N
Lanzavecchia, A
Fransen, J
Figdor, CG
Piguet, V
van Kooyk, Y
[J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (05) : 2118 - 2126

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