Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Recurrent Spontaneous Abortion in Chinese Han Women

被引：15

作者：

Xing, Xiuye ^{[1
,2
]}

Yan, Junhao ^{[1
,2
]}

Zhao, Yueran ^{[1
,2
]}

You, Li ^{[1
,2
]}

Bian, Yuehong ^{[1
,2
,3
]}

Chen, Zi-Jiang ^{[1
,2
]}

机构：

[1] Shandong Univ, Prov Hosp, Ctr Reprod Med, Jinan 250021, Shandong, Peoples R China

[2] Shandong Prov Key Lab Reprod Med, Jinan, Peoples R China

[3] Shandong Univ, Sch Med, Jinan 250021, Shandong, Peoples R China

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2011年 / 65卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Polymorphism; recurrent spontaneous abortion; vascular endothelial growth factor; PREGNANCY LOSS; VEGF GENE; ANGIOGENESIS; MISCARRIAGE; COMPLICATIONS; LETHALITY;

D O I：

10.1111/j.1600-0897.2010.00924.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Problem An association of polymorphism -1154G/A (rs1570360) in vascular endothelial growth factor (VEGF) gene with idiopathic recurrent spontaneous abortion (RSA) has been found in Caucasians. The aim of this study was to examine the association of VEGF -1154 with RSA in a well-defined group of Chinese Han patients. Method of study The VEGF -1154G/A genotype was detected by real-time PCR with TaqMan probes. The products were also subjected to gene sequence analysis to validate the PCR results. Results The allele frequencies of VEGF -1154G/A showed no significant difference between RSA patients and the normal controls (P = 0.183). The frequencies of VEGF -1154G/A genotypes were not significantly different between RSA patients and the normal controls (P = 0.228). Conclusion Our study revealed that VEGF -1154G/A polymorphism was not associated with the susceptibility to RSA in Chinese Han women.

引用

页码：521 / 525

页数：5

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