Immunotherapy for EBV-associated malignancies

被引:24
作者
Merlo, Anna [1 ]
Turrini, Riccardo [1 ]
Dolcetti, Riccardo [2 ]
Zanovello, Paola [1 ,3 ]
Rosato, Antonio [1 ,3 ]
机构
[1] Univ Padua, Dept Oncol & Surg Sci, I-35128 Padua, Italy
[2] Natl Canc Inst, Canc Bioimmunotherapy Unit, Dept Med Oncol, CRO,IRCCS, Aviano, Italy
[3] IOV IRCCS, Ist Oncol Veneto, Padua, Italy
关键词
EBV; CTL; PTLD; NPC; HL; EPSTEIN-BARR-VIRUS; CYTOTOXIC T-LYMPHOCYTES; STEM-CELL TRANSPLANTATION; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; IN-VIVO EXPANSION; NUCLEAR ANTIGEN 1; ADOPTIVE TRANSFER; NASOPHARYNGEAL CARCINOMA; HODGKINS-DISEASE; CORD BLOOD;
D O I
10.1007/s12185-011-0782-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since 1995 to date, more than 250 patients with EBV-related diseases received virus-specific CTL. Cell therapy proved to be safe and effective, and achieved some complete remissions also in patients who failed all previous standard treatments. The first clinical results with EBV-specific CTL were obtained for both prophylaxis and treatment of post-transplant lymphoproliferative disease arising in stem cell transplant or solid organ transplant recipients. Based on such encouraging results, the same approach was then extended to other EBV-related diseases, namely Hodgkin's lymphoma, nasopharyngeal carcinoma, and chronic active infection. Nowadays, the modification of the CTL generation protocols and the introduction of new specificities into EBV-specific CTL lines by chimeric antigen receptor transfer allow targeting other viral infections and also non-EBV related malignancies. Aim of this review is to summarize clinical results obtained thus far in adoptive cell therapy approaches with EBV-specific CTL. Moreover, by analyzing ongoing clinical trials, we also provide some insights on the potential future of a successful and paradigmatic history.
引用
收藏
页码:281 / 293
页数:13
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