Early Detection of Recurrent Ovarian Cancer in Patients with Low-Level Increases in Serum CA-125 Levels by 2-[F-18]Fluoro-2-Deoxy-D-Glucose-Positron Emission Tomography/Computed Tomography
被引:30
作者:
Peng, Nan-Jing
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机构:
Kaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
Natl Yang Ming Univ, Sch Med, Taipei 112, TaiwanKaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
Peng, Nan-Jing
[1
,2
]
Liou, Wen-Shiung
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Kaohsiung Vet Gen Hosp, Dept Obstet & Gynecol, Kaohsiung 813, TaiwanKaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
Liou, Wen-Shiung
[3
]
Liu, Ren-Shyan
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机构:
Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
Taipei Vet Gen Hosp, Dept Nucl Med, Taipei, TaiwanKaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
Liu, Ren-Shyan
[2
,4
]
Hu, Chin
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机构:
Kaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, TaiwanKaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
Hu, Chin
[1
]
Tsay, Daw-Guey
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Kaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, TaiwanKaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
Tsay, Daw-Guey
[1
]
Liu, Cheng-Bin
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机构:
Kaohsiung Vet Gen Hosp, Dept Obstet & Gynecol, Kaohsiung 813, TaiwanKaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
Liu, Cheng-Bin
[3
]
机构:
[1] Kaohsiung Vet Gen Hosp, Dept Nucl Med, Kaohsiung 813, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[3] Kaohsiung Vet Gen Hosp, Dept Obstet & Gynecol, Kaohsiung 813, Taiwan
[4] Taipei Vet Gen Hosp, Dept Nucl Med, Taipei, Taiwan
cancer;
FDG;
imaging;
PET;
ONCOLOGIC PET REGISTRY;
FOLLOW-UP;
F-18-FDG PET/CT;
NORMAL RANGE;
CA125;
NADIR;
FDG-PET/CT;
CARCINOMA;
PROGRESSION;
MANAGEMENT;
2-<FLUORINE-18>-FLUORO-2-DEOXY-D-GLUCOSE;
D O I:
10.1089/cbr.2010.0872
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Purpose: Serum CA-125 has been shown to be a sensitive tumor marker of recurrent ovarian cancer. The goal of this study was to evaluate the use of 2-[F-18]fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in the early detection of recurrent ovarian cancer in patients with low-level increases in serum CA-125 levels. Methods: Patients who demonstrated a normalization of serum CA-125 levels after complete remission of ovarian cancer were recruited for this study. FDG-PET/CT was performed to evaluate serum CA-125 levels >= 35 U/mL (Group 1) or progressive low-level increases in the levels of serum CA-125 (Group 2). The results were analyzed based on pathology, disease progression, and/or clinical follow-up. Results: Twenty-seven (27) consecutive patients consented to the aforementioned criteria (n = 16 in Group 1 and n = 11 in Group 2). In Group 1, of the 16 patients, 15 had a proven tumor recurrence, and the remaining 1 had a second primary cancer with no evidence of recurrent ovarian lesions. In Group 2, all 11 patients had recurrent tumors. The use of FDG-PET/CT allowed the detection of recurrences in 25 patients and a second primary cancer in 1 patient, which included all of the patients in Group 1 and 10 of the 11 patients in Group 2. The detection rate of FDG-PET/CT for recurrent ovarian cancer was 100% in Group 1 and 90.9% in Group 2 (15/15 vs. 10/11, p = 0.423). FDG-PET/CT changed the intended management in 14 (53.8%) of the patients, which included 4 cases in Group 1 and 10 cases in Group 2. Conclusions: FDG-PET/CT has the ability to detect recurrent ovarian cancer and second primary tumors in patients with increased levels of serum CA-125. FDG-PET/CT affects the clinical management by localizing recurrent lesions and creating a specific treatment plan for each patient, especially patients who demonstrate a low-level increase in serum CA-125 levels.
机构:
Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Hillner, Bruce E.
Siegel, Barry A.
论文数: 0引用数: 0
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机构:
Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, Div Nucl Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Siteman Canc Ctr, St Louis, MO 63110 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Siegel, Barry A.
Shields, Anthony F.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Karmanos Canc Inst, Detroit, MI USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Shields, Anthony F.
Liu, Dawei
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Ctr Stat Sci, Providence, RI 02912 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Liu, Dawei
Gareen, Ilana F.
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机构:
Brown Univ, Ctr Stat Sci, Providence, RI 02912 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Gareen, Ilana F.
Hunt, Ed
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h-index: 0
机构:
Brown Univ, Ctr Stat Sci, Providence, RI 02912 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Hunt, Ed
Coleman, R. Edward
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h-index: 0
机构:
Duke Univ, Sch Med, Dept Radiol, Durham, NC USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Iagaru, Andrei H.
Mittra, Erik S.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Mittra, Erik S.
McDougall, Iain Ross
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h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
McDougall, Iain Ross
Quon, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Quon, Andrew
Gambhir, Sanjiv Sam
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
机构:
Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Virginia Commonwealth Univ, Massey Canc Ctr, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Hillner, Bruce E.
Siegel, Barry A.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, Div Nucl Med, St Louis, MO 63110 USA
Washington Univ, Sch Med, Siteman Canc Ctr, St Louis, MO 63110 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Siegel, Barry A.
Shields, Anthony F.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Karmanos Canc Inst, Detroit, MI USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Shields, Anthony F.
Liu, Dawei
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Ctr Stat Sci, Providence, RI 02912 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Liu, Dawei
Gareen, Ilana F.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Ctr Stat Sci, Providence, RI 02912 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Gareen, Ilana F.
Hunt, Ed
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Ctr Stat Sci, Providence, RI 02912 USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
Hunt, Ed
Coleman, R. Edward
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Sch Med, Dept Radiol, Durham, NC USAVirginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23298 USA
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Iagaru, Andrei H.
Mittra, Erik S.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Mittra, Erik S.
McDougall, Iain Ross
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
McDougall, Iain Ross
Quon, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Quon, Andrew
Gambhir, Sanjiv Sam
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA
Stanford Hosp & Clin, Div Nucl Med, Dept Bioengn, Stanford, CA 94305 USAStanford Hosp & Clin, Div Nucl Med, Dept Radiol, Stanford, CA 94305 USA