Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents

被引：197

作者：

Dong, Yizhou ^{[1
,2
]}

Morris-Natschke, Susan L. ^{[1
,2
]}

Lee, Kuo-Hsiung ^{[1
,2
]}

机构：

[1] Univ N Carolina, Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA

[2] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung, Taiwan

来源：

NATURAL PRODUCT REPORTS | 2011年 / 28卷 / 03期

关键词：

SALVIA-MILTIORRHIZA BUNGE; CELLS IN-VITRO; HUMAN BREAST-CANCER; GERANYLGERANYL DIPHOSPHATE SYNTHASE; HEPATOCELLULAR-CARCINOMA CELLS; MINOR-GROOVE-BINDING; HAIRY ROOT CULTURES; NF-KAPPA-B; II-A; GROWTH-INHIBITION;

D O I：

10.1039/c0np00035c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tanshinones are a series of abietane diterpenes, isolated exclusively from Salvia miltiorrhiza and related species. More than 40 tanshinones and their analogs have been isolated since the 1930s. Their biosynthetic pathway correlates with the MEP/DOXP pathway, and many key enzymes, such as SmCPS, are responsible for establishing their molecular scaffolds and stereospecificity. Because of their unique structural characteristics and promising biological activities, total syntheses of various tanshinones have attracted the interest of many synthetic chemists, including R. H. Thomson, H. Kakisawa, R. L. Danheiser, Y. Inouye and J. K. Snyder. Tanshinones and their analogs exhibit interesting and broad antitumor activity in various cell and animal models. Most recently, the tanshinone analog neo-tanshinlactone has shown potent and selective activity against breast cancer. This review will discuss the biosynthesis, total syntheses, and antitumor activities of tanshinones, especially neo-tanshinlactone and its analogs.

引用

页码：529 / 542

页数：14

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