Animal models for meniscus repair and regeneration

被引：59

作者：

Deponti, Daniela ^{[1
]}

Di Giancamillo, Alessia ^{[2
]}

Scotti, Celeste ^{[1
]}

Peretti, Giuseppe M. ^{[1
,3
]}

Martin, Ivan ^{[4
,5
]}

机构：

[1] IRCCS Ist Ortoped Galeazzi, Milan, Italy

[2] Univ Milan, Fac Vet Med, I-20122 Milan, Italy

[3] Univ Milan, Dept Biomed Sci Hlth, I-20122 Milan, Italy

[4] Univ Basel Hosp, Dept Surg, CH-4031 Basel, Switzerland

[5] Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland

来源：

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | 2015年 / 9卷 / 05期

关键词：

animal model; meniscus; tissue engineering; regenerative medicine; scaffold; biomaterials; MESENCHYMAL STEM-CELLS; HUMAN KNEE-JOINT; SMALL-INTESTINE SUBMUCOSA; ARTICULAR-CARTILAGE; MENISCECTOMY MODEL; MEDIAL MENISCUS; GROWTH-FACTOR; SHEEP MODEL; GOAT MODEL; IN-VITRO;

D O I：

10.1002/term.1760

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The meniscus plays an important role in knee function and mechanics. Meniscal lesions, however, are common phenomena and this tissue is not able to achieve spontaneous successful repair, particularly in the inner avascular zone. Several animal models have been studied and proposed for testing different reparative approaches, as well as for studying regenerative methods aiming to restore the original shape and function of this structure. This review summarizes the gross anatomy, function, ultrastructure and biochemical composition of the knee meniscus in several animal models in comparison with the human meniscus. The relevance of the models is discussed from the point of view of basic research as well as of clinical translation for meniscal repair, substitution and regeneration. Finally, the advantages and disadvantages of each model for various research directions are critically discussed. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：512 / 527

页数：16

共 133 条

[1] Enhancement of the repair of meniscal wounds in the red-white zone (middle third) by the injection of bone marrow cells in canine animal model [J].