Prognostic values of L-type amino acid transporter 1 and CD98hc expression in breast cancer

被引:9
作者
Ichinoe, Masaaki [1 ]
Mikami, Tetuo [2 ]
Yanagisawa, Nobuyuki [3 ]
Yoshida, Tsutomu [1 ]
Hana, Kiyomi [4 ]
Endou, Hitoshi [4 ]
Okayasu, Isao [1 ]
Sengoku, Norihiko [5 ]
Ogata, Hideaki [6 ]
Saegusa, Makoto [1 ]
Shibuya, Kazutoshi [7 ]
Murakumo, Yoshiki [1 ]
机构
[1] Kitasato Univ, Dept Pathol, Sch Med, Sagamihara, Kanagawa, Japan
[2] Toho Univ, Dept Pathol, Sch Med, Ota Ku, Tokyo, Japan
[3] St Marianna Univ, Sch Med, Dept Pathol, Yokohama City Seibu Hosp, Yokohama, Kanagawa, Japan
[4] J Pharma Co Ltd, Yokohama, Kanagawa, Japan
[5] Kitasato Univ, Dept Breast & Thyroid Surg, Sch Med, Sagamihara, Kanagawa, Japan
[6] Toho Univ, Dept Surg, Omori Med Ctr, Ota Ku, Tokyo, Japan
[7] Toho Univ, Dept Surg Pathol, Sch Med, Ota Ku, Tokyo, Japan
关键词
breast cancer; breast pathology; histopathology; POOR-PROGNOSIS; HEAVY-CHAIN; LAT1; APOPTOSIS; BIOMARKER; MARKER;
D O I
10.1136/jclinpath-2020-206457
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Aims L-type amino acid transporter 1 (LAT1) is a major Na+-independent neutral amino acid transporter, forming a complex with CD98hc. The aim of this study is to investigate the significance of LAT1 and CD98hc in invasive breast cancer. Methods LAT1 and CD98hc expression was immunohistochemically assessed in 280 invasive breast cancers and analysed for association with clinicopathological features. Results High levels of LAT1 and CD98hc were observed in triple-negative breast cancers (TNBCs) possessing negative immunoreactivity with oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, compared with non-TNBCs (NTNBCs), and were associated with lymph-node metastasis and higher nuclear grade. The high-LAT1-expression group showed a poor prognosis in NTNBC and TNBC, however, high-CD98hc-expression group showed a poor prognosis only in NTNBC. LAT1 and CD98hc expression could be the prognostic factors in univariate analyses, but not in multivariate analyses. Further, we found that invasive tumour components showed higher LAT1 and CD98hc expression than non-invasive tumour components. Conclusions LAT1 and CD98hc may possess prognostic values in invasive breast cancer. LAT1 may be linked with cancer cell activities and disease progression in breast cancer.
引用
收藏
页码:589 / 595
页数:7
相关论文
共 35 条
[1]   Triple-negative breast cancer in the older population [J].
Boyle, P. .
ANNALS OF ONCOLOGY, 2012, 23 :7-12
[2]   ROLE OF AMINO-ACID-TRANSPORT AND COUNTERTRANSPORT IN NUTRITION AND METABOLISM [J].
CHRISTENSEN, HN .
PHYSIOLOGICAL REVIEWS, 1990, 70 (01) :43-77
[3]   Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis [J].
Furuya, Mio ;
Horiguchi, Jun ;
Nakajima, Hiroki ;
Kanai, Yoshikatsu ;
Oyama, Tetsunari .
CANCER SCIENCE, 2012, 103 (02) :382-389
[4]   The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model [J].
Hafliger, Pascal ;
Graff, Julien ;
Rubin, Matthias ;
Stooss, Amandine ;
Dettmer, Matthias S. ;
Altmann, Karl-Heinz ;
Gertsch, Jurg ;
Charles, Roch-Philippe .
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018, 37
[5]   Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas [J].
Haining, Zhen ;
Kawai, Nobuyuki ;
Miyake, Keisuke ;
Okada, Masaki ;
Okubo, Shuichi ;
Zhang, Xiang ;
Fei, Zhou ;
Tamiya, Takashi .
BMC CLINICAL PATHOLOGY, 2012, 12
[6]   L-type amino acid transporter 1 expression is upregulated and associated with cellular proliferation in colorectal cancer [J].
Hayase, Suguru ;
Kumamoto, Kensuke ;
Saito, Katsuharu ;
Kofunato, Yasuhide ;
Sato, Yu ;
Okayama, Hirokazu ;
Miyamoto, Kotaro ;
Ohki, Shinji ;
Takenoshita, Seiichi .
ONCOLOGY LETTERS, 2017, 14 (06) :7410-7416
[7]   Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes [J].
Heaphy, Christopher M. ;
Subhawong, Andrea Proctor ;
Gross, Amy L. ;
Konishi, Yuko ;
Kouprina, Nina ;
Argani, Pedram ;
Visvanathan, Kala ;
Meeker, Alan K. .
MODERN PATHOLOGY, 2011, 24 (02) :194-200
[8]   Differences in clinical importance of Bcl-2 in breast cancer according to hormone receptors status or adjuvant endocrine therapy [J].
Honma, Naoko ;
Horii, Rie ;
Ito, Yoshinori ;
Saji, Shigehira ;
Younes, Mamoun ;
Iwase, Takuji ;
Akiyama, Futoshi .
BMC CANCER, 2015, 15
[9]   High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non-cancerous lesions [J].
Ichinoe, Masaaki ;
Mikami, Tetuo ;
Yoshida, Tsutomu ;
Igawa, Ikuyo ;
Tsuruta, Tomoko ;
Nakada, Norihiro ;
Anzai, Naohiko ;
Suzuki, Yoshiyuki ;
Endou, Hitoshi ;
Okayasu, Isao .
PATHOLOGY INTERNATIONAL, 2011, 61 (05) :281-289
[10]  
Imai H, 2010, ANTICANCER RES, V30, P4819