New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

被引：85
作者：
Souto, Eliana B. [1 ,2 ]
Ribeiro, Andre F. [1 ]
Ferreira, Maria I. [1 ]
Teixeira, Maria C. [1 ]
Shimojo, Andrea A. M. [1 ,3 ]
Soriano, Jose L. [4 ]
Naveros, Beatriz C. [4 ]
Durazzo, Alessandra [5 ]
Lucarini, Massimo [5 ]
Souto, Selma B. [6 ]
Santini, Antonello [7 ]
机构：
[1] Univ Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, P-3000548 Coimbra, Portugal
[2] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal
[3] Univ Estadual Campinas, Dept Engn Mat & Bioproc, Sch Chem Engn, BR-13083852 Campinas, SP, Brazil
[4] Univ Granada, Fac Pharm, Dept Pharm & Pharmaceut Technol, E-18071 Granada, Spain
[5] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy
[6] Hosp Sao Joao, Dept Endocrinol, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal
[7] Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 02期
关键词：
burn wound infection; antibiotics; wound healing; nanoparticles; IN-VITRO; SILVER NANOPARTICLE; WOUND DRESSINGS; DRUG-DELIVERY; EX-VIVO; CHITOSAN; NANOEMULSIONS; RELEASE; FORMULATION; FILMS;
D O I：
10.3390/ijms21020393
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.
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页数：18
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