The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

被引：232
作者：
Kenyon, Cynthia [1 ]
机构：
[1] Univ Calif San Francisco, San Francisco, CA 94158 USA
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 366卷 / 1561期
关键词：
daf-2; daf-16; FOXO; history; insulin; IFG-1; NEMATODE CAENORHABDITIS-ELEGANS; LIFE-SPAN; C-ELEGANS; GENETIC-ANALYSIS; DAUER FORMATION; PHOSPHATIDYLINOSITOL-3; KINASE; SACCHAROMYCES-CEREVISIAE; REGULATES LONGEVITY; INTERACTING GENES; FAMILY-MEMBER;
D O I：
10.1098/rstb.2010.0276
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
引用
收藏
页码：9 / 16
页数：8
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