The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

被引：237

作者：

Kenyon, Cynthia ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94158 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 366卷 / 1561期

关键词：

daf-2; daf-16; FOXO; history; insulin; IFG-1; NEMATODE CAENORHABDITIS-ELEGANS; LIFE-SPAN; C-ELEGANS; GENETIC-ANALYSIS; DAUER FORMATION; PHOSPHATIDYLINOSITOL-3; KINASE; SACCHAROMYCES-CEREVISIAE; REGULATES LONGEVITY; INTERACTING GENES; FAMILY-MEMBER;

D O I：

10.1098/rstb.2010.0276

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.

引用

页码：9 / 16

页数：8

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