Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium

被引：28

作者：

Binder, David C. ^{[1
,2
]}

Arina, Ainhoa ^{[2
,3
]}

Wen, Frank ^{[2
]}

Tu, Tony ^{[2
,3
]}

Zhao, Ming ^{[4
]}

Hoffman, Robert M. ^{[4
,5
]}

Wainwright, Derek A. ^{[6
,7
]}

Schreiber, Hans ^{[1
,2
,3
]}

机构：

[1] Univ Chicago, Comm Canc Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA

[3] Univ Chicago, Comm Immunol, Chicago, IL 60637 USA

[4] AntiCancer Inc, San Diego, CA USA

[5] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA

[6] Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL 60611 USA

[7] Northwestern Univ, Feinberg Sch Med, Northwestern Brain Tumor Inst, Chicago, IL 60611 USA

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 06期

关键词：

Adoptive T cell therapy; bacteria; macrophage; relapse; tumor stroma; ANTIGEN-LOSS VARIANTS; ESTABLISHED TUMORS; CANCER; MELANOMA; DESTRUCTION; ERADICATION; REJECTION; RESPONSES;

D O I：

10.1080/2162402X.2015.1130207

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses and eradicates long-established tumors refractory to aCTLA-4 and aPD-L1 checkpoint inhibitor blockade. Here, we show that live intravenously injected or heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not producing tumor antigen, synergize with adoptive T cell therapy to eradicate tumors. These data demonstrate that the combination of adoptive T cell transfer with the injection of live or dead Salmonella typhimurium is a promising approach for cancer treatment.

引用

页数：7

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