Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study

被引:13
作者
Beyene, Habtamu B. [1 ,2 ]
Olshansky, Gavriel [1 ]
Giles, Corey [1 ]
Huynh, Kevin [1 ]
Cinel, Michelle [1 ]
Mellett, Natalie A. [1 ]
Smith, Adam Alexander T. [1 ]
Shaw, Jonathan E. [3 ,4 ]
Magliano, Dianna J. [3 ,4 ]
Meikle, Peter J. [1 ,2 ]
机构
[1] Baker Heart & Diabet Inst, Metabol Lab, Melbourne, Vic 3004, Australia
[2] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3004, Australia
[3] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia
[4] Baker Heart & Diabet Inst, Melbourne, Vic 3004, Australia
基金
英国医学研究理事会;
关键词
plasma lipidomics; change in WC; change in BMI; metabolic scores; WAIST CIRCUMFERENCE; SKELETAL-MUSCLE; WEIGHT CHANGE; ACYLCARNITINES;
D O I
10.3390/metabo11090646
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of lipid metabolism in relation to weight gain. Here, we investigated the relationship of the human plasma lipidome and changes in waist circumference (WC) and body mass index (BMI). Adults (2653 men and 3196 women), 25-95 years old who attended the baseline survey of the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) and the 5-year follow-up were enrolled. A targeted lipidomic approach was used to quantify 706 distinct molecular lipid species in the plasma samples. Multiple linear regression models were used to examine the relationship between the baseline lipidomic profile and changes in WC and BMI. Metabolic scores for change in WC were generated using a ridge regression model. Alkyl-diacylglycerol such as TG(O-50:2) [NL-18:1] displayed the strongest association with change in WC (beta-coefficient = 0.125 cm increment per SD increment in baseline lipid level, p = 2.78 x 10(-11). Many lipid species containing linoleate (18:2) fatty acids were negatively associated with both WC and BMI gain. Compared to traditional models, multivariate models containing lipid species identify individuals at a greater risk of gaining WC: top quintile relative to bottom quintile (odds ratio, 95% CI = 5.4, 3.8-6.6 for women and 2.3, 1.7-3.0 for men). Our findings define metabolic profiles that characterize individuals at risk of weight gain or WC increase and provide important insight into the biological role of lipids in obesity.
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页数:21
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