Urinary Carnosinase-1 Excretion is Associated with Urinary Carnosine Depletion and Risk of Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Cohort Study

被引：3

作者：

Rodriguez-Nino, Angelica ^{[1
,2
]}

Pastene, Diego O. ^{[2
]}

Post, Adrian ^{[1
]}

Said, M. Yusof ^{[1
]}

Gomes-Neto, Antonio W. ^{[1
]}

Kieneker, Lyanne M. ^{[1
]}

Heiner-Fokkema, M. Rebecca ^{[3
]}

Esatbeyoglu, Tuba ^{[4
]}

Rimbach, Gerald ^{[5
]}

Schnuelle, Peter ^{[2
,6
]}

Yard, Benito A. ^{[2
]}

Bakker, Stephan J. L. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9700 RB Groningen, Netherlands

[2] Heidelberg Univ, Med Fac Mannheim, Dept Nephrol Endocrinol & Rheumatol, Dept Med 5, D-68167 Mannheim, Germany

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, NL-9713 GZ Groningen, Netherlands

[4] Leibniz Univ Hannover, Inst Food Sci & Human Nutr, D-30167 Hannover, Germany

[5] Christian Albrechts Univ Kiel, Inst Human Nutr & Food Sci, D-24118 Kiel, Germany

[6] Ctr Renal Dis, D-69469 Weinheim, Germany

来源：

ANTIOXIDANTS | 2021年 / 10卷 / 07期

关键词：

carnosine; carnosinase-1; kidney transplantation; oxidative stress; graft failure; OXIDATIVE STRESS; DIABETIC-NEPHROPATHY; GLOMERULAR-FILTRATION; COST-EFFECTIVENESS; LEUCINE REPEAT; SURVIVAL; CNDP1; MALONDIALDEHYDE; METABOLISM; MORTALITY;

D O I：

10.3390/antiox10071102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carnosine affords protection against oxidative and carbonyl stress, yet high concentrations of the carnosinase-1 enzyme may limit this. We recently reported that high urinary carnosinase-1 is associated with kidney function decline and albuminuria in patients with chronic kidney disease. We prospectively investigated whether urinary carnosinase-1 is associated with a high risk for development of late graft failure in kidney transplant recipients (KTRs). Carnosine and carnosinase-1 were measured in 24 h urine in a longitudinal cohort of 703 stable KTRs and 257 healthy controls. Cox regression was used to analyze the prospective data. Urinary carnosine excretions were significantly decreased in KTRs (26.5 [IQR 21.4-33.3] mu mol/24 h versus 34.8 [IQR 25.6-46.8] mu mol/24 h; p < 0.001). In KTRs, high urinary carnosinase-1 concentrations were associated with increased risk of undetectable urinary carnosine (OR 1.24, 95%CI [1.06-1.45]; p = 0.007). During median follow-up for 5.3 [4.5-6.0] years, 84 (12%) KTRs developed graft failure. In Cox regression analyses, high urinary carnosinase-1 excretions were associated with increased risk of graft failure (HR 1.73, 95%CI [1.44-2.08]; p < 0.001) independent of potential confounders. Since urinary carnosine is depleted and urinary carnosinase-1 imparts a higher risk for graft failure in KTRs, future studies determining the potential of carnosine supplementation in these patients are warranted.

引用

页数：17

共 67 条

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