Iodine-Mediated Cross-Dehydrogenative Coupling of Heterocyclic Thiols with Amines: An Easy and Practical Formation of S-N Bond

被引：10

作者：

Wu, Yue-Xiao ^{[1
]}

Peng, Kang ^{[1
]}

Hu, Zhi-Chao ^{[1
]}

Fan, Yong-Hao ^{[1
]}

Shi, Zhen ^{[2
]}

Hao, Er-Jun ^{[3
]}

Dong, Zhi-Bing ^{[1
,2
,3
,4
,5
]}

机构：

[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China

[2] Hubei Minzu Univ, Hubei Key Lab Biol Resources Protect & Utilizat, Enshi 445000, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

[4] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Wuhan 430205, Peoples R China

[5] Wuhan Inst Technol, Hubei Key Lab Novel Reactor & Green Chem Technol, Wuhan 430205, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 43期

关键词：

Cross-dehydrogenative coupling; Metal-free; S-N bond; Sulfenamide; Synthesis; CHEMISTRY; SULFENAMIDES; DISULFIDES; MOLECULES;

D O I：

10.1002/ejoc.202101165

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient iodine-mediated construction of S-N bond was developed. Such a cross-dehydrogenative coupling of heterocyclic thiols with amines proceeded smoothly under metal-free and base-free conditions, and afforded a series of sulfenamides in good to excellent yields. The easily available substrates and convenient synthetic procedure illustrate potential synthetic value of this protocol for the preparation of sulfenamide related biologically or pharmaceutically active compounds.

引用

页码：5889 / 5894

页数：6

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