Correlation of Calcium and Magnesium Levels in the Biological Samples of Different Types of Acute Leukemia Children

被引：12
作者：
Afridi, Hasan Imran [1 ]
Kazi, Tasneem Gul [1 ]
Talpur, Farah Naz [1 ]
机构：
[1] Univ Sindh, Natl Ctr Excellence Analyt Chem, Jamshoro 76080, Pakistan
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2018年 / 186卷 / 02期
关键词：
Acute leukemia; Atomic absorption spectrophotometer; Age groups (1-10years); Biological samples; Calcium; Children; Magnesium; ACUTE-LYMPHOBLASTIC-LEUKEMIA; MULTIPLE OSTEOLYTIC LESIONS; MYELOID-LEUKEMIA; HODGKINS-DISEASE; ADULT PATIENT; HYPERCALCEMIA; BONE; COPPER; CHEMOTHERAPY; INDUCTION;
D O I：
10.1007/s12011-018-1340-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Acute leukemia (AL) is a common childhood malignancy. It is clinically and morphologically heterogeneous. The present work was intended to estimate the concentration of calcium (Ca) and magnesium (Mg) in serum and whole blood samples of children having AL; 1- to 5- and 6- to 10-year-old children age group was chosen of both genders. Healthy children of the same age group were selected as controls for comparative study. For sample pretreatment, a microwave-assisted acid digestion (MAD) was carried out, to assess the concentration of Ca and Mg in biological samples of AL children. The MAD method was validated by analyzing Clinchek (R) Control certified samples of whole blood and serum. Ca and Mg were analyzed in the digested samples by flame atomic absorption spectrometry (FAAS). The results showed significantly higher concentration of Ca, whereas lower contents of Mg in the serum and whole blood of AL children in both genders, as compared to healthy subjects. The data provide assistance to physician/clinicians and other professional staffs to investigate the imbalance of minerals in biological samples of AL children.
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收藏
页码：395 / 406
页数：12
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