t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?

被引：0

作者：

Feng, Jianhua ^{[1
,4
]}

Leung, Alex W. K. ^{[1
]}

Cheng, Frankie W. T. ^{[1
]}

Lam, Grace K. S. ^{[1
]}

Chow, Terry T. W. ^{[1
]}

Ng, Margaret H. L. ^{[2
]}

Chu, Winnie C. W. ^{[3
]}

Chan, Natalie P. H. ^{[2
]}

Li, Chi-kong ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anatomincal & Cellular Pathol, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Diagnost Radiol & Organ Imaging, Hong Kong, Peoples R China

[4] Wenzhou Med Univ, Dept Paediat, Affiliated Hosp 1, Wenzhou, Peoples R China

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2021年 / 43卷 / 08期

关键词：

acute megakaryoblastic leukemia; t(1; 22); hepatic fibrosis; tretinoin; alpha-tocopheryl acetate; TRANS-RETINOIC ACID; FATTY LIVER-DISEASE; VITAMIN-E; CHILDREN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: There is no established effective treatment for patients with t(1;22)(p13;q13) acute megakaryoblastic leukemia (AMKL) and hepatic fibrosis. Observation: Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died from liver failure despite the control of leukemia. The other patient was successfully treated with reduced-intensity chemotherapy and anti-fibrosis therapy with tretinoin and alpha-tocopheryl acetate, the hepatic fibrosis resolved and leukemia was in remission for 3 years. Conclusions: Reduced-intensity chemotherapy plus anti-fibrosis therapy with tretinoin and alpha-tocopheryl acetate could be a treatment option for these patients with t(1;22)(p13;q13) AMKL and hepatic fibrosis.

引用

页码：E1164 / E1167

页数：4

共 19 条

[1]

BECROFT D M O, 1990, Pediatric Pathology, V10, P397

[2] Effect of cyanidin 3-O-β-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress [J].

Bendia, E ;

Benedetti, A ;

Baroni, GS ;

Candelaresi, C ;

Macarri, G ;

Trozzi, L ;

Di Sario, A .

DIGESTIVE AND LIVER DISEASE, 2005, 37 (05) :342-348

[3] Nineteen cases of the t(1;22)(p13;q13) acute megakaryoblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group [J].

Bernstein, J ;

Dastugue, N ;

Haas, OA ;

Harbott, J ;

Heerema, NA ;

Huret, JL ;

Landman-Parker, J ;

LeBeau, MM ;

Leonard, C ;

Mann, G ;

Pages, MP ;

Perot, C ;

Pirc-Danoewinata, H ;

Roitzheim, B ;

Rubin, CM ;

Slociak, M ;

Viguie, F .

LEUKEMIA, 2000, 14 (01) :216-218

[4] Effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload [J].

Brown, KE ;

Poulos, JE ;

Li, L ;

Soweid, AM ;

Ramm, GA ;

ONeil, R ;

Britton, RS ;

Bacon, BR .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 272 (01) :G116-G123

[5]

CARROLL A, 1991, BLOOD, V78, P748

[6]

GAREL D, 1991, NOUV REV FR HEMATOL, V33, P5

[7] All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production [J].

Hisamori, Shigeo ;

Tabata, Chiharu ;

Kadokawa, Yoshio ;

Okoshi, Kae ;

Tabata, Rie ;

Mori, Akira ;

Nagayama, Satoshi ;

Watanabe, Go ;

Kubo, Hajime ;

Sakai, Yoshiharu .

LIVER INTERNATIONAL, 2008, 28 (09) :1217-1225

[8] Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study [J].

Inaba, Hiroto ;

Zhou, Yinmei ;

Abla, Oussama ;

Adachi, Souichi ;

Auvrignon, Anne ;

Beverloo, H. Berna ;

de Bont, Eveline ;

Chang, Tai-Tsung ;

Creutzig, Ursula ;

Dworzak, Michael ;

Elitzur, Sarah ;

Fynn, Alcira ;

Forestier, Erik ;

Hasle, Henrik ;

Liang, Der-Cherng ;

Lee, Vincent ;

Locatelli, Franco ;

Masetti, Riccardo ;

De Moerloose, Barbara ;

Reinhardt, Dirk ;

Rodriguez, Laura ;

Van Roy, Nadine ;

Shen, Shuhong ;

Taga, Takashi ;

Tomizawa, Daisuke ;

Yeoh, Allen E. J. ;

Zimmermann, Martin ;

Raimondi, Susana C. .

BLOOD, 2015, 126 (13) :1575-1584

[9] Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis [J].

Kinjo, Tadamune ;

Inoue, Hirosuke ;

Kusuda, Takeshi ;

Fujiyoshi, Junko ;

Ochiai, Masayuki ;

Takahata, Yasushi ;

Honjo, Satoshi ;

Koga, Yuhki ;

Hara, Toshiro ;

Ohga, Shouichi .

PEDIATRICS AND NEONATOLOGY, 2019, 60 (04) :382-388

[10] Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents The TONIC Randomized Controlled Trial [J].

Lavine, Joel E. ;

Schwimmer, Jeffrey B. ;

Van Natta, Mark L. ;

Molleston, Jean P. ;

Murray, Karen F. ;

Rosenthal, Philip ;

Abrams, Stephanie H. ;

Scheimann, Ann O. ;

Sanyal, Arun J. ;

Chalasani, Naga ;

Tonascia, James ;

Uenalp, Aynur ;

Clark, Jeanne M. ;

Brunt, Elizabeth M. ;

Kleiner, David E. ;

Hoofnagle, Jay H. ;

Robuck, Patricia R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (16) :1659-1668

← 1 2 →