Chemical Composition, Antibacterial and Cytotoxic Activities of the Essential Oil from Ficus tikoua Bur.

被引：14
作者：
Tian, Minyi [1 ,2 ]
Zhao, Xiaoge [2 ]
Wu, Xianghuan [2 ]
Hong, Yi [1 ]
Chen, Qi [1 ]
Liu, Xiongli [2 ]
Zhou, Ying [2 ,3 ]
机构：
[1] Guizhou Univ, Inst Agrobioengn, Coll Life Sci,Minist Educ,Key Lab Plant Resource, Collaborat Innovat Ctr Mt Ecol & Agrobioengn CICM, Guiyang 550025, Peoples R China
[2] Guizhou Univ, Guizhou Engn Ctr Innovat Tradit Chinese Med & Eth, Guiyang 550025, Peoples R China
[3] Guizhou Univ Tradit Chinese Med, Coll Pharm, Guiyang 550025, Peoples R China
来源：
RECORDS OF NATURAL PRODUCTS | 2020年 / 14卷 / 03期
基金：
国家重点研发计划;
关键词：
Ficus tikoua Bur; essential oil; GC-MS; palmitic acid; antibacterial activity; cytotoxic activity; FREE FATTY-ACIDS; PALMITIC ACID; APOPTOSIS; L; CONSTITUENTS;
D O I：
10.25135/rnp.161.19.10.1450
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The chemical composition and biological activities of the essential oil from Ficus tikoua Bur. were reported for the first time. Fifty-three compounds, accounting for 99.60% of the total essential oil composition, were identified and the main components were palmitic acid (51.13%) and linoleic acid (47.54%). The essential oil revealed significant antibacterial activity with the inhibition zones (7.89-10.59 mm), MIC (0.20-6.25 mg/mL) and MBC (0.20-12.50 mg/mL) against Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Proteus vulgaris. The essential oil exhibited significant cytotoxicity against A549, NCI-H1299, PC-3 and K562 tumor cells with the IC50 values of 131.08, 50.32, 120.58 and 31.68 mu g/mL, respectively. The essential oil exhibited selective cytotoxic activity to human tumor cell lines, with a significantly lower cytotoxicity to human normal cell line (MRC-5, IC50 = 161.75 mu g/mL) than to tumor cells. Additionally, palmitic acid, as the major compound, aslo revealed significant antibacterial and cytotoxic activities.
引用
收藏
页码：219 / 224
页数：6
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