Psychopathology among offspring of parents with substance abuse and/or anxiety disorders: A high-risk study

被引：167
作者：
Merikangas, KR
Dierker, LC
Szatmari, P
机构：
[1] Yale Univ, Sch Med, Genet Epidemiol Res Unit, New Haven, CT 06510 USA
[2] McMaster Univ, Hamilton, ON, Canada
来源：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY | 1998年 / 39卷 / 05期
关键词：
alcohol abuse; drug abuse; anxiety; family factors; risk factors;
D O I：
10.1017/S0021963098002522
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
This paper reports the results of a high-risk study of children under age 18 of parents who served as probands in a family study of comorbidity of substance abuse and anxiety disorders. There was a strong degree of specificity of familial aggregation of both the anxiety disorders and substance disorders. Rates of conduct disorder and depression were elevated among offspring of all affected parents. Inclusion of co-parent disorders in the evaluation of familial transmission in the present study strengthened the findings regarding the specificity of transmission of the anxiety disorders and the links between both parental substance abuse and antisocial personality with child conduct disorder.
引用
收藏
页码：711 / 720
页数：10
相关论文
共 50 条
[21]   Investigating the association between anxiety symptoms and mood disorder in high-risk offspring of bipolar parents: a comparison of Joint and Cox models [J].
Ruoxi Dong ;
George Stefan ;
Julie Horrocks ;
Sarah M. Goodday ;
Anne Duffy .
International Journal of Bipolar Disorders, 7
[22]   Investigating the association between anxiety symptoms and mood disorder in high-risk offspring of bipolar parents: a comparison of Joint and Cox models [J].
Dong, Ruoxi ;
Stefan, George ;
Horrocks, Julie ;
Goodday, Sarah M. ;
Duffy, Anne .
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, 2019, 7 (01)
[23]   Substance abuse in parents and their adolescent offspring: The role of sexual maturation and sensation seeking [J].
Kirillova, GP ;
Vanyukov, MM ;
Gavaler, JS ;
Pajer, K ;
Dunn, M ;
Tarter, RE .
JOURNAL OF CHILD & ADOLESCENT SUBSTANCE ABUSE, 2001, 10 (04) :77-89
[24]   Anxiety and substance abuse disorders-Focus on alcohol and cannabis [J].
Hellwig, Sabine ;
Domschke, Katharina .
NERVENARZT, 2023, 94 (7) :647-654
[25]   Fear-potentiated startle in adolescent offspring of parents with anxiety disorders [J].
Grillon, C ;
Dierker, L ;
Merikangas, KR .
BIOLOGICAL PSYCHIATRY, 1998, 44 (10) :990-997
[26]   Facilitating Versus Inhibiting the Transmission of Drug Abuse from High-Risk Parents to Their Children: A Swedish National Study [J].
Kendler, Kenneth S. ;
Ohlsson, Henrik ;
Sundquist, Jan ;
Sundquist, Kristina .
TWIN RESEARCH AND HUMAN GENETICS, 2020, 23 (01) :1-7
[27]   Diminished error-related brain activity as a promising endophenotype for substance-use disorders: evidence from high-risk offspring [J].
Euser, Anja S. ;
Evans, Brittany E. ;
Greaves-Lord, Kirstin ;
Huizink, Anja C. ;
Franken, Ingmar H. A. .
ADDICTION BIOLOGY, 2013, 18 (06) :970-984
[28]   Identifying psychophysiological risk for psychopathology: Examples from substance abuse and schizophrenia research [J].
Iacono, WG .
PSYCHOPHYSIOLOGY, 1998, 35 (06) :621-637
[29]   An Epidemiological Study of Substance Use Disorders Among Emerging and Young Adults [J].
Qadeer, Rana A. ;
Georgiades, Kathy ;
Boyle, Michael H. ;
Ferro, Mark A. .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2019, 64 (05) :313-322
[30]   Weighing psychosocial factors in relatives for the risk of psychopathology: a study of patients with depressive and anxiety disorders and their siblings [J].
Eleonore D. van Sprang ;
Dominique F. Maciejewski ;
Yuri Milaneschi ;
Marie-Louise J. Kullberg ;
Bernet M. Elzinga ;
Albert M. van Hemert ;
Catharina A. Hartman ;
Brenda W. J. H. Penninx .
Social Psychiatry and Psychiatric Epidemiology, 2023, 58 :1213-1226
12345