Psychopathology among offspring of parents with substance abuse and/or anxiety disorders: A high-risk study

被引:174
作者
Merikangas, KR
Dierker, LC
Szatmari, P
机构
[1] Yale Univ, Sch Med, Genet Epidemiol Res Unit, New Haven, CT 06510 USA
[2] McMaster Univ, Hamilton, ON, Canada
关键词
alcohol abuse; drug abuse; anxiety; family factors; risk factors;
D O I
10.1017/S0021963098002522
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
This paper reports the results of a high-risk study of children under age 18 of parents who served as probands in a family study of comorbidity of substance abuse and anxiety disorders. There was a strong degree of specificity of familial aggregation of both the anxiety disorders and substance disorders. Rates of conduct disorder and depression were elevated among offspring of all affected parents. Inclusion of co-parent disorders in the evaluation of familial transmission in the present study strengthened the findings regarding the specificity of transmission of the anxiety disorders and the links between both parental substance abuse and antisocial personality with child conduct disorder.
引用
收藏
页码:711 / 720
页数:10
相关论文
共 50 条
  • [21] Investigating the association between anxiety symptoms and mood disorder in high-risk offspring of bipolar parents: a comparison of Joint and Cox models
    Dong, Ruoxi
    Stefan, George
    Horrocks, Julie
    Goodday, Sarah M.
    Duffy, Anne
    [J]. INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, 2019, 7 (01)
  • [22] Substance abuse in parents and their adolescent offspring: The role of sexual maturation and sensation seeking
    Kirillova, GP
    Vanyukov, MM
    Gavaler, JS
    Pajer, K
    Dunn, M
    Tarter, RE
    [J]. JOURNAL OF CHILD & ADOLESCENT SUBSTANCE ABUSE, 2001, 10 (04) : 77 - 89
  • [23] Anxiety and substance abuse disorders-Focus on alcohol and cannabis
    Hellwig, Sabine
    Domschke, Katharina
    [J]. NERVENARZT, 2023, 94 (7): : 647 - 654
  • [24] Fear-potentiated startle in adolescent offspring of parents with anxiety disorders
    Grillon, C
    Dierker, L
    Merikangas, KR
    [J]. BIOLOGICAL PSYCHIATRY, 1998, 44 (10) : 990 - 997
  • [25] Facilitating Versus Inhibiting the Transmission of Drug Abuse from High-Risk Parents to Their Children: A Swedish National Study
    Kendler, Kenneth S.
    Ohlsson, Henrik
    Sundquist, Jan
    Sundquist, Kristina
    [J]. TWIN RESEARCH AND HUMAN GENETICS, 2020, 23 (01) : 1 - 7
  • [26] Diminished error-related brain activity as a promising endophenotype for substance-use disorders: evidence from high-risk offspring
    Euser, Anja S.
    Evans, Brittany E.
    Greaves-Lord, Kirstin
    Huizink, Anja C.
    Franken, Ingmar H. A.
    [J]. ADDICTION BIOLOGY, 2013, 18 (06) : 970 - 984
  • [27] Identifying psychophysiological risk for psychopathology: Examples from substance abuse and schizophrenia research
    Iacono, WG
    [J]. PSYCHOPHYSIOLOGY, 1998, 35 (06) : 621 - 637
  • [28] An Epidemiological Study of Substance Use Disorders Among Emerging and Young Adults
    Qadeer, Rana A.
    Georgiades, Kathy
    Boyle, Michael H.
    Ferro, Mark A.
    [J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2019, 64 (05): : 313 - 322
  • [29] Weighing psychosocial factors in relatives for the risk of psychopathology: a study of patients with depressive and anxiety disorders and their siblings
    Eleonore D. van Sprang
    Dominique F. Maciejewski
    Yuri Milaneschi
    Marie-Louise J. Kullberg
    Bernet M. Elzinga
    Albert M. van Hemert
    Catharina A. Hartman
    Brenda W. J. H. Penninx
    [J]. Social Psychiatry and Psychiatric Epidemiology, 2023, 58 : 1213 - 1226
  • [30] Pattern of Risks for Psychiatric and Substance Use Disorders in the Offspring of Parents With Alcohol Use Disorder
    Kendler, Kenneth S.
    Abrahamsson, Linda
    Sundquist, Jan
    Sundquist, Kristina
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2024, 181 (04) : 322 - 329