Efficient 2-aryl benzothiazole formation from acetophenones, anilines, and elemental sulfur by iodine-catalyzed oxidative C(CO)-C(alkyl) bond cleavage

被引：28

作者：

Liu, Yafeng ^{[1
]}

Yuan, Xinglong ^{[1
]}

Guo, Xin ^{[1
]}

Zhang, Xueguo ^{[1
]}

Chen, Baohua ^{[1
]}

机构：

[1] Lanzhou Univ, Dept Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou, Gansu, Peoples R China

来源：

TETRAHEDRON | 2018年 / 74卷 / 41期

基金：

中国国家自然科学基金;

关键词：

Benzothiazoles; Acetophenones; Anilines; Elemental sulfur; C-C bond cleavage; C-S; 2-SUBSTITUTED BENZOTHIAZOLES; SUBSTITUTED BENZOTHIAZOLES; 3-COMPONENT SYNTHESIS; COPPER; BENZOXAZOLES; POTENT; 2-ARYLBENZOTHIAZOLE; FUNCTIONALIZATION; ANALOGS;

D O I：

10.1016/j.tet.2018.08.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient iodine-catalyzed one-pot reaction of aromatic amines, acetophenones, and elemental sulfur for the synthesis of 2-aryl benzothiazoles is described. The process involves sequential C-S and C-N bond formation followed by C(CO)-C bond cleavage from readily accessible starting materials. A wide range of functional groups is tolerated under oxidant and metal-free condition and moderate to good product yields are obtained. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：6057 / 6062

页数：6

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