Ultrasound-induced biophysical effects in controlled drug delivery

被引：21
作者：
Zhang, Lulu [1 ]
Lin, Zhuohua [1 ]
Zeng, Lan [1 ]
Zhang, Fan [1 ]
Sun, Lihong [1 ]
Sun, Suhui [1 ]
Wang, Ping [1 ]
Xu, Menghong [1 ]
Zhang, Jinxia [1 ]
Liang, Xiaolong [1 ]
Ge, Huiyu [1 ]
机构：
[1] Peking Univ Third Hosp, Dept Ultrasound, Beijing 100191, Peoples R China
来源：
SCIENCE CHINA-LIFE SCIENCES | 2022年 / 65卷 / 05期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
ultrasound; biophysical effects; drug delivery systems; ultrasound parameters; ultrasound-triggered drug delivery; INTENSITY FOCUSED ULTRASOUND; TARGETED MICROBUBBLE DESTRUCTION; TEMPERATURE-SENSITIVE LIPOSOMES; TRIGGERED DRUG; MEDIATED DELIVERY; RADIATION FORCE; PHOSPHOLIPID MICROBUBBLES; RADIOFREQUENCY ABLATION; MULTIDRUG-RESISTANCE; LOCAL HYPERTHERMIA;
D O I：
10.1007/s11427-021-1971-x
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery. Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers. This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency, including the characteristics of drug delivery carriers and ultrasound parameters. Firstly, biophysical effects induced by ultrasound, namely thermal effects, cavitation effects, and acoustic radiation forces, are illustrated. Secondly, the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail. Thirdly, recent advances in ultrasound-triggered drug delivery are detailed. Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized. Finally, current progress and future directions are discussed.
引用
收藏
页码：896 / 908
页数：13
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