MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R

被引:15
作者
Zou, Zeng Cheng [1 ]
Dai, Min [1 ]
Huang, Zeng Yin [2 ]
Lu, Yi [3 ]
Xie, He Ping [1 ]
Li, Yi Fang [4 ]
Li, Yue [1 ]
Tan, Ying [5 ]
Wang, Feng Lin [1 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Integrated Tradit & Western Med, 600 Tianhe Rd, Guangzhou 510630, Guangdong, Peoples R China
[2] Guangdong Prov Hosp Tradit Chinese Med, Dept Oncol, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, Guangzhou, Guangdong, Peoples R China
[4] Guangdong Prov Hosp Tradit Chinese Med, Dept Acupuncture, Guangzhou, Guangdong, Peoples R China
[5] Guangdong Prov Family Planning Res Inst, Dept Infertil & Steril, Guangzhou, Guangdong, Peoples R China
关键词
MicroRNA 139-3p (miR-139-3p); Hepatocellular carcinoma (HCC); Annexin A2 receptor (ANXA2R); Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER-CELL-PROLIFERATION; SIGNALING PATHWAY; BREAST-CANCER; COLON-CANCER; LUNG-CANCER; OSTEOSARCOMA; PROGRESSION; EXPRESSION; APOPTOSIS;
D O I
10.3727/096504018X15178798885361
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R expression.
引用
收藏
页码:1391 / 1399
页数:9
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