Recyclization of 2-iminocoumarin-3-carbonitriles with 2-aminothiobenzamide: a new synthetic route to substituted 2-(2-iminocoumarin-3-yl)quinazoline-4(3H)-thiones

被引：5

作者：

Shynkarenko, Pavlo E. ^{[1
]}

Vlasov, Sergiy V. ^{[1
]}

Kovalenko, Sergiy M. ^{[1
]}

Chernykh, Valentin P. ^{[1
]}

机构：

[1] Natl Univ Pharm, Dept Organ Chem, UA-61002 Kharkov, Ukraine

来源：

JOURNAL OF SULFUR CHEMISTRY | 2010年 / 31卷 / 05期

关键词：

iminocoumarin; quinazoline; thiobenzamide; rearrangement; recyclization; KNOEVENAGEL CONDENSATION; NUCLEOPHILIC-REAGENTS; ANTICANCER AGENTS; COUMARIN MOIETIES; QUINAZOLINE RING; HETEROCYCLES; DERIVATIVES; 2-IMINO-2H-1-BENZOPYRANS; CYCLIZATION; SYSTEMS;

D O I：

10.1080/17415993.2010.509506

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of 2-aminothiobenzamide with either 2-iminocoumarin-3-carbonitrile or 2-iminocoumarin-3-thiocarboxamides has been studied. It has been established that in both cases, 2-(2-iminocoumarin-3-yl)quinazoline-4(3H)-thiones are formed as the result of a two-step procedure. The reactions of 2-(2-iminocoumarin-3-yl)quinazoline-4(3H)-thiones with arylamines and alkylating agents have been studied.

引用

页码：447 / 456

页数：10

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