Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases

被引：53
作者：
Niture, Suryakant [1 ]
Lin, Minghui [2 ]
Qi, Qi [1 ]
Moore, John T. [1 ]
Levine, Keith E. [3 ]
Fernando, Reshan A. [3 ]
Kumar, Deepak [1 ]
机构：
[1] North Carolina Cent Univ, Julius L Chambers Biomed Biotechnol Res Inst, Durham, NC 27707 USA
[2] Fourth Peoples Hosp Ningxia Hui Autonomous Reg, Yinchuan 750021, Ningxia, Peoples R China
[3] RTI Int, Durham, NC 27709 USA
来源：
JOURNAL OF TOXICOLOGY | 2021年 / 2021卷
基金：
美国国家卫生研究院;
关键词：
CELL-CYCLE PROGRESSION; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; INDUCED TOXICITY; MALIGNANT-TRANSFORMATION; EXPOSURE; CANCER; SELENIUM; INJURY; KEY;
D O I：
10.1155/2021/9564297
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Cadmium (Cd) is a toxic pollutant that is associated with several severe human diseases. Cd can be easily absorbed in significant quantities from air contamination/industrial pollution, cigarette smoke, food, and water and primarily affects the liver, kidney, and lungs. Toxic effects of Cd include hepatotoxicity, nephrotoxicity, pulmonary toxicity, and the development of various human cancers. Cd is also involved in the development and progression of fatty liver diseases and hepatocellular carcinoma. Cd affects liver function via modulation of cell survival/proliferation, differentiation, and apoptosis. Moreover, Cd dysregulates hepatic autophagy, an endogenous catabolic process that detoxifies damaged cell organelles or dysfunctional cytosolic proteins through vacuole-mediated sequestration and lysosomal degradation. In this article, we review recent developments and findings regarding the role of Cd in the modulation of hepatotoxicity, autophagic function, and liver diseases at the molecular level.
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页数：14
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