Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

被引:153
作者
Borena, Bizunesh M. [1 ,2 ]
Martens, Ann [3 ]
Broeckx, Sarah Y. [4 ,5 ]
Meyer, Evelyne [6 ]
Chiers, Koen [7 ]
Duchateau, Luc [1 ]
Spaas, Jan H. [4 ,5 ]
机构
[1] Univ Ghent, Fac Vet Med, Dept Comparat Physiol & Biometr, Merelbeke, Belgium
[2] Ambo Univ, Coll Agr & Vet Sci, Dept Vet Lab, Ambo, Ethiopia
[3] Univ Ghent, Fac Vet Med, Dept Surg & Anesthesiol Domest Anim, Merelbeke, Belgium
[4] ANACURA Grp, Global Stem Cell Technol, Evergem, Belgium
[5] ANACURA Grp, Pell Cell Med, Evergem, Belgium
[6] Univ Ghent, Fac Vet Med, Dept Pharmacol Toxicol & Biochem, Merelbeke, Belgium
[7] Univ Ghent, Fac Vet Med, Dept Pathol Bacteriol & Poultry Dis, Merelbeke, Belgium
关键词
Skin; Wound healing; Growth factor; Stem cell; PLATELET-RICH PLASMA; T-LYMPHOCYTE PROLIFERATION; MESENCHYMAL STROMAL CELLS; MARROW-DERIVED CELLS; HUMAN ADIPOSE-TISSUE; BONE-MARROW; LOWER-EXTREMITY; EXTRACELLULAR-MATRIX; CLINICAL-EVALUATION; DERMAL FIBROBLASTS;
D O I
10.1159/000374049
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Mammal skin has a crucial function in several life-preserving processes such as hydration, protection against chemicals and pathogens, initialization of vitamin D synthesis, excretion and heat regulation. Severe damage of the skin may therefore be life-threatening. Skin wound repair is a multiphased, yet well-orchestrated process including the interaction of various cell types, growth factors and cytokines aiming at closure of the skin and preferably resulting in tissue repair. Regardless various therapeutic modalities targeting at enhancing wound healing, the development of novel approaches for this pathology remains a clinical challenge. The time-consuming conservative wound management is mainly restricted to wound repair rather than restitution of the tissue integrity (the so-called "restitutio ad integrum"). Therefore, there is a continued search towards more efficacious wound therapies to reduce health care burden, provide patients with long-term relief and ultimately scarless wound healing. Recent in vivo and in vitro studies on the use of skin wound regenerative therapies provide encouraging results, but more protracted studies will have to determine whether the effect of observed effects are clinically significant and whether regeneration rather than repair can be achieved. For all the aforementioned reasons, this article reviews the emerging field of regenerative skin wound healing in mammals with particular emphasis on growth factor- and stem cell-based therapies. Copyright (C) 2015 S. Karger AG, Basel
引用
收藏
页码:1 / 23
页数:23
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