Advances in refolding of proteins produced in E-coli

被引：366

作者：

Lilie, H ^{[1
]}

Schwarz, E ^{[1
]}

Rudolph, R ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Biotechnol, D-06120 Halle, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(98)80035-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Inclusion body production is a common theme in recombinant protein technology. Hence, renaturation of these inclusion body proteins is a field of increasing interest for gaining large amounts of proteins. Recent developments of renaturation procedures include the inhibition of aggregation during refolding by the application of low molecular weight additives and matrix-bound renaturation techniques.

引用

页码：497 / 501

页数：5

共 44 条

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