Total synthesis of microsclerodermin E

被引：58

作者：

Zhu, JD ^{[1
]}

Ma, DW ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 43期

关键词：

amino acids; Julia reaction; macrocycles; pepticles; total synthesis;

D O I：

10.1002/anie.200352423

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Succumbing to total synthesis: Microsclerodermin E, a 23-membered cyclic hexapeptide possessing antifungal activity, has been prepared for the first time. Key features in the synthesis include the construction of four unusual amino acid units, the assembly of the pyrrolidinone fragment with little racemization, and an effective macrocyclization.

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收藏

页码：5348 / 5351

页数：4

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