Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors

被引：64
作者：
Weber, F
Fukino, K
Sawada, T
Williams, N
Sweet, K
Brena, RM
Plass, C
Caldes, T
Mutter, GL
Villalona-Calero, MA
Eng, C
机构：
[1] Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA
[2] Ohio State Univ, Coll Med & Publ Hlth, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
[3] Ohio State Univ, Ctr Comprehens Canc, Clin Canc Genet Program, Columbus, OH 43210 USA
[4] Ohio State Univ, Coll Med & Publ Hlth, Dept Internal Med, Div Human Genet, Columbus, OH 43210 USA
[5] San Carlos Univ Hosp, Mol Oncol Lab, Madrid 28040, Spain
[6] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[7] Ohio State Univ, Coll Med & Publ Hlth, Dept Internal Med, Div Hematol Oncol, Columbus, OH 43210 USA
[8] Univ Cambridge, Canc Res UK Human Canc Genet Res Grp, Cambridge CB2 1XZ, England
来源：
BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 10期
关键词：
small-molecule therapy; tyrosine kinase; EGFR mutation; breast cancer;
D O I：
10.1038/sj.bjc.6602557
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Organ-specific differences in epidermal growth factor receptor ( EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy.
引用
收藏
页码：1922 / 1926
页数：5
相关论文
共 7 条
[1]   Targeting epidermal growth factor receptor - are we missing the mark? [J].
Dancey, JE ;
Freidlin, B .
LANCET, 2003, 362 (9377) :62-64
[2]   Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets [J].
Fukino, K ;
Lei, S ;
Matsumoto, S ;
Morrison, CD ;
Mutter, GL ;
Eng, C .
CANCER RESEARCH, 2004, 64 (20) :7231-7236
[3]   High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan [J].
Huang, SF ;
Liu, HP ;
Li, LH ;
Ku, YC ;
Fu, YN ;
Tsai, HY ;
Chen, YT ;
Lin, YF ;
Chang, WC ;
Kuo, HP ;
Wu, YC ;
Chen, YR ;
Tsai, SF .
CLINICAL CANCER RESEARCH, 2004, 10 (24) :8195-8203
[4]   Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions [J].
Kurose, K ;
Hoshaw-Woodard, S ;
Adeyinka, A ;
Lemeshow, S ;
Watson, PH ;
Eng, C .
HUMAN MOLECULAR GENETICS, 2001, 10 (18) :1907-1913
[5]   Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas [J].
Kurose, K ;
Gilley, K ;
Matsumoto, S ;
Watson, PH ;
Zhou, XP ;
Eng, C .
NATURE GENETICS, 2002, 32 (03) :355-357
[6]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[7]   EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].
Paez, JG ;
Jänne, PA ;
Lee, JC ;
Tracy, S ;
Greulich, H ;
Gabriel, S ;
Herman, P ;
Kaye, FJ ;
Lindeman, N ;
Boggon, TJ ;
Naoki, K ;
Sasaki, H ;
Fujii, Y ;
Eck, MJ ;
Sellers, WR ;
Johnson, BE ;
Meyerson, M .
SCIENCE, 2004, 304 (5676) :1497-1500
1