Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products

被引：84

作者：

Chandrasekaran, C. V. ^{[1
]}

Deepak, H. B. ^{[1
]}

Thiyagarajan, P. ^{[1
]}

Kathiresan, S. ^{[1
]}

Sangli, Gopal Krishna ^{[1
]}

Deepak, M. ^{[1
]}

Agarwal, Amit ^{[1
]}

机构：

[1] Nat Remedies Pvt Ltd, R&D Ctr, Bangalore, Karnataka, India

来源：

PHYTOMEDICINE | 2011年 / 18卷 / 04期

关键词：

Glycyrrhiza glabra; Phytoconstituents; (glabridin; isoliquiritigenin; glycyrrhizin); Inflammation; COX products (PGE(2); TXB(2)); LOX product (LTB(4)); ANTIOXIDANT ACTIVITY; ACID-DERIVATIVES; EXPRESSION; LEUKOTRIENES; INFLAMMATION; MACROPHAGES; ROOTS;

D O I：

10.1016/j.phymed.2010.08.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Glycyrrhiza glabra and its phytoconstituents have been known to possess widespread pharmacological properties as an anti-inflammatory, anti-viral, antitumour and hepatoprotective drug. In this study, we examined the inhibitory potential of extract of G. glabra (GutGard (TM)) root and its phytoconstituents (glabridin, glycyrrhizin, and isoliquiritigenin) on both cyclooxygenase (COX) and lipoxygenase (LOX) products in order to understand the mechanism of its anti-inflammatory action. Inhibitory effect of GutGard (TM) and its phytoconstituents on lipopolysaccharide (LPS) induced prostaglandin E(2) (PGE(2)), calcimycin (A23187) induced thromboxane (TXB(2)), and leukotriene (LTB(4)) release was studied using murine macrophages (J774A.1) and human neutrophil (HL-60) cells. Results revealed that, G. glabra and glabridin significantly inhibited PGE(2), TXB(2) (COX) and LTB(4) (LOX), while, isoliquiritigenin exerted inhibitory effect only against COX products but failed to suppress LOX product. However, glycyrrhizin at the tested concentrations failed to exhibit inhibitory effect on both COX and LOX products. Here, we report for the first time that G. glabra (almost devoid of glycyrrhizin) exhibits anti-inflammatory property likely through the inhibition of PGE(2). TXB(2) and LTB(4) in mammalian cell assay system, which could be influenced in part by glabridin and isoliquiritigenin. (C) 2010 Elsevier GmbH. All rights reserved.

引用

页码：278 / 284

页数：7

共 24 条

[1] MECHANISM OF ANTIINFLAMMATORY ACTION OF GLYCYRRHIZIN - EFFECT ON NEUTROPHIL FUNCTIONS INCLUDING REACTIVE OXYGEN SPECIES GENERATION [J].

AKAMATSU, H ;

KOMURA, J ;

ASADA, Y ;

NIWA, Y .

PLANTA MEDICA, 1991, 57 (02) :119-121

[2]

Ambawade Shirish D., 2002, Indian Journal of Pharmacology, V34, P251

[3] LEUKOTRIENES AND INFLAMMATION [J].

BRAIN, SD ;

WILLIAMS, TJ .

PHARMACOLOGY & THERAPEUTICS, 1990, 46 (01) :57-66

[4] Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs [J].

Charlier, C ;

Michaux, C .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (7-8) :645-659

[5]

COLLINS SJ, 1987, BLOOD, V70, P1233

[6] Prostaglandins and leukotrienes: Advances in eicosanoid biology [J].

Funk, CD .

SCIENCE, 2001, 294 (5548) :1871-1875

[7] Clinical perspectives of anti-inflammatory therapy in the elderly: the lipoxigenase (LOX)/cycloxigenase (COX) inhibition concept [J].

Gaddi, A ;

Cicero, AFG ;

Pedro, EJ .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2004, 38 (03) :201-212

[8]

HEROLD A, 2003, ARCH MICROBIOL IMMUN, V62, P117

[9]

INOUE H, 1986, CHEM PHARM BULL, V34, P897

[10]

KAKEGAWA H, 1992, CHEM PHARM BULL, V40, P1439

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