Another Horse in the Meta-Stable State of Pluripotency

被引：5

作者：

Cherry, Anne ^{[1
,2
,3
]}

Daley, George Q. ^{[1
,2
,3
]}

机构：

[1] Childrens Hosp, Stem Cell Transplantat Program, Div Pediat Hematol Oncol, Manton Ctr Orphan Dis Res,Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dana Farber Canc Inst, Div Hematol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Harvard Stem Cell Inst, Boston, MA 02115 USA

来源：

CELL STEM CELL | 2010年 / 7卷 / 06期

关键词：

EMBRYONIC STEM-CELLS; SUBPOPULATIONS;

D O I：

10.1016/j.stem.2010.11.020

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Reports of heterogeneity within embryonic stem cell lines suggest that pluripotent stem cells captured in culture may be less homogeneous than previously assumed. In a recent issue of Cell, Scholer and colleagues (Han et al., 2010) demonstrate the existence of a dynamic subpopulation of epiblast stem cells that shows features of earlier pluripotent cells.

引用

收藏

页码：641 / 642

页数：2

相关论文

共 9 条

[1] Derivation of pluripotent epiblast stem cells from mammalian embryos [J].

Brons, I. Gabrielle M. ;

Smithers, Lucy E. ;

Trotter, Matthew W. B. ;

Rugg-Gunn, Peter ;

Sun, Bowen ;

de Sousa Lopes, Susana M. Chuva ;

Howlett, Sarah K. ;

Clarkson, Amanda ;

Ahrlund-Richter, Lars ;

Pedersen, Roger A. ;

Vallier, Ludovic .

NATURE, 2007, 448 (7150) :191-U7

[2] Different Flavors of Pluripotency, Molecular Mechanisms, and Practical Implications (vol 7, pg 559, 2010) [J].

Buecker, Christa ;

Geijsen, Niels .

CELL STEM CELL, 2010, 7 (06) :759-759

[3] The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells [J].

Chou, Yu-Fen ;

Chen, Hsu-Hsin ;

Eijpe, Maureen ;

Yabuuchi, Akiko ;

Chenoweth, Joshua G. ;

Tesar, Paul ;

Lu, Jun ;

Mckay, Ronald D. G. ;

Geijsen, Niels .

CELL, 2008, 135 (03) :449-461

[4] Klf4 reverts developmentally programmed restriction of ground state pluripotency [J].

Guo, Ge ;

Yang, Jian ;

Nichols, Jennifer ;

Hall, John Simon ;

Eyres, Isobel ;

Mansfield, William ;

Smith, Austin .

DEVELOPMENT, 2009, 136 (07) :1063-1069

[5] Epiblast Stem Cell Subpopulations Represent Mouse Embryos of Distinct Pregastrulation Stages [J].

Han, Dong Wook ;

Tapia, Natalia ;

Joo, Jin Young ;

Greber, Boris ;

Arauzo-Bravo, Marcos J. ;

Bernemann, Christof ;

Ko, Kinarm ;

Wu, Guangming ;

Stehling, Martin ;

Do, Jeong Tae ;

Schoeler, Hans R. .

CELL, 2010, 143 (04) :617-627

[6] Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs [J].

Hanna, Jacob ;

Cheng, Albert W. ;

Saha, Krishanu ;

Kim, Jongpil ;

Lengner, Christopher J. ;

Soldner, Frank ;

Cassady, John P. ;

Muffat, Julien ;

Carey, Bryce W. ;

Jaenisch, Rudolf .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (20) :9222-9227

[7] Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States [J].

Hayashi, Katsuhiko ;

Lopes, Susana M. Chuva de Sousa ;

Tang, Fuchou ;

Surani, M. Azim .

CELL STEM CELL, 2008, 3 (04) :391-401

[8] New cell lines from mouse epiblast share defining features with human embryonic stem cells [J].

Tesar, Paul J. ;

Chenoweth, Josh G. ;

Brook, Frances A. ;

Davies, Timothy J. ;

Evans, Edward P. ;

Mack, David L. ;

Gardner, Richard L. ;

McKay, Ronald D. G. .

NATURE, 2007, 448 (7150) :196-U10

[9] Identification and characterization of subpopulations in undifferentiated ES cell culture [J].

Toyooka, Yayoi ;

Shimosato, Daisuke ;

Murakami, Kazuhiro ;

Takahashi, Kadue ;

Niwa, Hitoshi .

DEVELOPMENT, 2008, 135 (05) :909-918