pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates

被引：66

作者：

Ji, Xingyue

De La Cruz, Ladie Kimberly C.

Pan, Zhixiang

Chittavong, Vayou

Wang, Binghe ^{[1
]}

机构：

[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 69期

关键词：

CO-RELEASE; STRUCTURAL-CHARACTERIZATION; DRUG-DELIVERY; LIVING CELLS; MOLECULES; COMPLEXES; DERIVATIVES; PHOTOCORM; LIGHT; CLICK;

D O I：

10.1039/c7cc04866a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbon monoxide prodrugs with triggered release profiles are highly desirable for targeted CO delivery to minimize their untoward side-effects. Herein, we describe a series of pH-sensitive metal-free CO prodrugs which are stable under acidic conditions and yet begin to release CO in response to increases in pH with tunable and predictable release rates.

引用

收藏

页码：9628 / 9631

页数：4

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