Short Communication: Low seroprevalence of cryptococcal antigenaemia in patients with advanced HIV infection enrolling in an antiretroviral programme in Ghana

被引：19

作者：

Mamoojee, Yaasir ^{[1
]}

Shakoor, Shaid ^{[1
]}

Gorton, Rebecca L. ^{[2
]}

Sarfo, Stephen ^{[3
]}

Appiah, Lambert T. ^{[3
]}

Norman, Betty ^{[3
]}

Balakrishnan, Indran ^{[2
]}

Phillips, Richard ^{[3
]}

Chadwick, David ^{[1
]}

机构：

[1] James Cook Univ Hosp, Dept Infect & Travel Med, Middlesbrough TS4 3BW, Cleveland, England

[2] Royal Free Hosp, Dept Microbiol, London NW3 2QG, England

[3] Komfo Anokye Teaching Hosp, Dept Med, Kumasi, Ghana

来源：

TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2011年 / 16卷 / 01期

关键词：

Cryptococcus; HIV; Africa; epidemiology; cryptococcal antigen; VIH; Afrique; epidemiologie; antigene cryptococcal; Criptococo; epidemiologia; antigeno; HUMAN-IMMUNODEFICIENCY-VIRUS; COHORT; POPULATION; MORTALITY; THERAPY; UGANDA; ADULTS;

D O I：

10.1111/j.1365-3156.2010.02683.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objectives To determine the prevalence of cryptococcal antigenaemia in a clinic population with advanced HIV infection, with a view to giving antifungal therapy to those testing positive. Methods Serum samples from adults with CD4 count < 100 cells/mm3 presenting to a large HIV clinic in Kumasi, Ghana, were tested retrospectively for cryptococcal antigenaemia using a latex agglutination assay, and clinical and demographic data extracted from case notes. Results Of 92 samples tested, two were positive thus giving a prevalence of 2% (95% CI, 0-5.2%). Conclusions The prevalence of cryptococcal antigenaemia in patients with advanced HIV infection enrolling in an antiretroviral programme appears to be low in Kumasi, suggesting that the value of routine testing of outpatients diagnosed with advanced HIV infection may be limited in this population.

引用

页码：53 / 56

页数：4

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