Postlearning consolidation of birdsong: Stabilizing effects of age and anterior forebrain lesions

被引:108
作者
Brainard, MS
Doupe, AJ
机构
[1] Univ Calif San Francisco, Keck Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
关键词
basal ganglia; song learning; motor learning; memory consolidation; timing; language; speech; auditory feedback; hearing loss; deafness;
D O I
10.1523/JNEUROSCI.21-07-02501.2001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Birdsong is a learned. sequenced motor skill. For the zebra finch, learned song normally remains unchanging beyond early adulthood. However, stable adult song will gradually deteriorate after deafening (Nordeen and Nordeen, 1992), indicating an ongoing influence of auditory feedback on learned song. This plasticity of adult song in response to deafening gradually declines with age (Lombardino and Nottebohm, 2000), suggesting that, after song learning, there continue to be changes in the brain that progressively stabilize the song motor program. A qualitatively similar stabilization of learned song can be precipitated artificially by lesions of a basal ganglia circuit in the songbird anterior forebrain (Brainard and Doupe, 2000), raising the question of whether and how these two forms of song stabilization are related. We investigated this issue by characterizing the deterioration of song that occurs after deafening in young adult birds and the degree to which that deterioration is reduced by age or by lesions of the anterior forebrain that were directed at the lateral portion of the magnocellular nucleus of the anterior neostriatum (LMAN). In most respects, LMAN lesions stabilized song to a significantly greater extent than did aging; whereas old-deafened birds eventually exhibited significant deterioration of song, lesioned-deafened birds generally did not differ from controls. The one exception was for song tempo, which was significantly stabilized by age, but not by LMAN lesions. The results indicate that LMAN lesions do not simply mimic a normal aging process, and likewise suggest that the anterior forebrain pathway continues to play a role even in the residual song plasticity that is observed after the age-dependent stabilization of song.
引用
收藏
页码:2501 / 2517
页数:17
相关论文
共 68 条
[1]   The temporal control of repetitive articulatory movements in Parkinson's disease [J].
Ackermann, H ;
Konczak, J ;
Hertrich, I .
BRAIN AND LANGUAGE, 1997, 56 (02) :312-319
[2]   EFFECTS OF CASTRATION ON SONG DEVELOPMENT IN ZEBRA FINCHES (POEPHILA-GUTTATA) [J].
ARNOLD, AP .
JOURNAL OF EXPERIMENTAL ZOOLOGY, 1975, 191 (02) :261-277
[3]   Blockade of NMDA receptors in the anterior forebrain impairs sensory acquisition in the zebra finch (Poephila guttata) [J].
Basham, ME ;
Nordeen, EJ ;
Nordeen, KW .
NEUROBIOLOGY OF LEARNING AND MEMORY, 1996, 66 (03) :295-304
[4]   MECHANISMS OF AVIAN IMPRINTING - A REVIEW [J].
BOLHUIS, JJ .
BIOLOGICAL REVIEWS, 1991, 66 (04) :303-345
[5]   FOREBRAIN LESIONS DISRUPT DEVELOPMENT BUT NOT MAINTENANCE OF SONG IN PASSERINE BIRDS [J].
BOTTJER, SW ;
MIESNER, EA ;
ARNOLD, AP .
SCIENCE, 1984, 224 (4651) :901-903
[6]   CASTRATION AND ANTISTEROID TREATMENT IMPAIR VOCAL LEARNING IN MALE ZEBRA FINCHES [J].
BOTTJER, SW ;
HEWER, SJ .
JOURNAL OF NEUROBIOLOGY, 1992, 23 (04) :337-353
[7]  
Bottjer SW, 1997, J NEUROBIOL, V33, P602, DOI 10.1002/(SICI)1097-4695(19971105)33:5<602::AID-NEU8>3.0.CO
[8]  
2-8
[9]   Sex differences in neuropeptide staining of song-control nuclei in zebra finch brains [J].
Bottjer, SW ;
Roselinsky, H ;
Tran, NB .
BRAIN BEHAVIOR AND EVOLUTION, 1997, 50 (05) :284-303
[10]  
Brainard MS, 1998, J NEUROSCI, V18, P3929