Proton Beam Therapy in Elderly Patients With cT1-3N0M0 Non-small Cell Lung Cancer

被引：5

作者：

Nakamura, Masatoshi ^{[1
]}

Ishikawa, Hitoshi ^{[1
,2
]}

Ohnishi, Kayoko ^{[1
,3
]}

Baba, Keiichiro ^{[1
]}

Saito, Takashi ^{[1
]}

Sumiya, Taisuke ^{[1
]}

Murakami, Motohiro ^{[1
]}

Hiroshima, Yuichi ^{[1
]}

Nakai, Kei ^{[1
]}

Mizumoto, Masashi ^{[1
]}

Okumura, Toshiyuki ^{[1
]}

Sakurai, Hideyuki ^{[1
]}

机构：

[1] Univ Tsukuba, Fac Med, Dept Radiat Oncol, Tsukuba, Ibaraki, Japan

[2] QST Hosp, Natl Inst Quantum Sci & Technol, Chiba, Japan

[3] Int Univ Hlth & Welf, Sch Med, Dept Radiol, Narita, Japan

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 06期

关键词：

Proton beam therapy; elderly patients; non-small cell lung cancer; BODY RADIATION-THERAPY; PNEUMONITIS; RADIOTHERAPY; IMPACT; DISEASE; SURVIVAL;

D O I：

10.21873/anticanres.15778

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: To investigate the outcomes of elderly patients with cT1-3N0M0 non-small cell lung cancer (NSCLC) undergoing proton beam therapy (PBT). Patients and Methods: Between 2009 and 2019, 110 patients receiving hypofractionated PBT for cT1-3N0M0 NSCLC were retrospectively reviewed. Results: The median followup was 36.5 months (range=4.9-131.0 months). In the elderly group (80 years or older), the 3-year overall survival and progression-free survival rates were 79.8% and 73.9%, respectively, and the corresponding rates in the younger group were 80.5% and 61.2%, respectively. Grade 3 radiation pneumonitis (RP) was observed in 4.4% patients in the young group, whereas no grade 3 RP was observed in the elderly group. Age was not a risk factor for symptomatic RP. There were no significant differences in the survival and adverse events between the elderly and younger groups. Conclusion: PBT may be a reasonable approach for treating lung cancer in elderly patients with T1-3N0M0 NSCLC.

引用

页码：2953 / 2960

页数：8

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