Direct and Efficient (Carbonyl)cobalt-Mediated Aryl Acetylation Using [11C] Methyl Iodide

被引：5

作者：

Dahl, Kenneth ^{[1
]}

Schou, Magnus ^{[2
]}

Halldin, Christer ^{[1
]}

机构：

[1] Karolinska Istitutet, Dept Clin Neurosci, Ctr Psychiat Res, Karolinska Hosp, S-17176 Stockholm, Sweden

[2] Karolinska Inst, AstraZeneca Translat Sci Ctr, Dept Clin Neurosci, S-17176 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 16期

关键词：

Radiochemistry; Carbon-11; Positron emission tomography; Carbonylation; Cobalt; Carbonyl ligands; PET; RADIOLIGANDS; PRESSURE; TRIFLATE;

D O I：

10.1002/ejoc.201600085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy is reported that allows direct access to C-11-labelled aryl methyl ketones by a fast and efficient (carbonyl) cobalt-mediated protocol employing [C-11] methyl iodide as the labelling agent. The method uses Co2CO8 as combined aryl halide activator and carbon monoxide source for the carbonylation reaction. The suitability of the methodology was demonstrated by the C-11-labelling of a set of functionalised arenes and heteroarenes with radiochemical conversions (RCC) ranging from 22 % to 63 %.

引用

页码：2775 / 2777

页数：3