Differential effects of interleukin-4 in peptide induced autoimmunity

被引：14
作者：
Deocharan, B
Marambio, P
Edelman, M
Putterman, C
机构：
[1] Albert Einstein Coll Med, Div Rheumatol, Dept Med, Bronx, NY 10461 USA
[2] Winthrop Univ Hosp, Dept Pathol, Mineola, NY 11501 USA
[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
来源：
CLINICAL IMMUNOLOGY | 2003年 / 108卷 / 02期
关键词：
SLE; peptide mimetope; anti-DNA antibodies; autoantibodies; glomerulonephritis; interleukin-4; cytokines;
D O I：
10.1016/S1521-6616(03)00096-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
BALB/c mice immunized with multimeric DWEYSVWLSN develop IgG1 anti-DNA antibodies and glomerular immunoglobulin deposits, leading us to investigate the role of IL-4 in this model of antigen induced lupus. Splenocytes from DWEYSVWLSN immunized mice secreted IL-4 but not gamma-interferon. Following peptide immunization, IgG1 anti-peptide and anti-DNA antibodies were significantly higher in IL-4 wild type mice, while IgM and IgG3 anti-DNA levels were significantly higher in IL-4 knockout mice. Titers of IgG anti-laminin and anti-histone, but not anti-Sm/RNP and anti-cardiolipin antibodies, were significantly higher in the IL-4 wild type group. Glomerular immunoglobulin deposition was substantially decreased in IL-4 knockout mice. We conclude that while IL-4 does not materially affect the generation of some autoantibody responses associated with peptide induced autoimmunity, IL-4 deficiency inhibits kidney immunoglobulin deposition. The effect of IL-4 on humoral autoimmunity in lupus is complex, and is dependent on genetic background, the antigenic trigger and stage of disease. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码：80 / 88
页数：9
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