Inflammasome: A Double-Edged Sword in Liver Diseases

被引：87
作者：
Luan, Jingyun
Ju, Dianwen [1 ]
机构：
[1] Fudan Univ, Sch Pharm, Minist Educ, Dept Microbiol & Biochem Pharm, Shanghai, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
inflammasome; liver; pyroptosis; innate immune; adaptive immune; metabolism; NLRP3; INFLAMMASOME; DYSBIOSIS CONTRIBUTES; HEPATOCYTE PYROPTOSIS; STERILE INFLAMMATION; FATTY-ACID; ACTIVATION; OBESITY; MECHANISMS; PROTEIN; CELLS;
D O I：
10.3389/fimmu.2018.02201
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammasomes have emerged as critical innate sensors of host immune that defense against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in the liver. The assembly of inflammasome activates caspase-1, which promotes the maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18), and initiates pyroptotic cell death (pyroptosis). IL-18 exerts pleiotropic effects on hepatic NK cells, priming FasL-mediated cytotoxicity, and interferon-gamma (IFN-gamma)-dependent responses to prevent the development of liver diseases. However, considerable attention has been attracted to the pathogenic role of inflammasomes in various acute and chronic liver diseases, including viral hepatitis, nanoparticle-induced liver injury, alcoholic and non-alcoholic steatohepatitis. In this review, we summarize the latest advances on the physiological and pathological roles of inflammasomes for further development of inflammasome-based therapeutic strategies for human liver diseases.
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页数：8
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