Lactate dehydrogenase in sickle cell disease

被引：27
作者：
Stojanovic, Katia Stankovic [1 ]
Lionnet, Francois [1 ]
机构：
[1] Univ Paris 06, Hop Tenon, AP HP, Ctr Reference Adulte Drepanocytose,Serv Med Inter, Paris, France
来源：
CLINICA CHIMICA ACTA | 2016年 / 458卷
关键词：
Lactate dehydrogenase; Hemolysis; Sickle cell disease; Prognosis; RISK-FACTORS; PULMONARY-HYPERTENSION; ALPHA-THALASSEMIA; HEMOLYTIC-ANEMIA; LEG ULCERATION; CHILDREN; ADOLESCENTS; PREVALENCE; ADULTS; DEATH;
D O I：
10.1016/j.cca.2016.04.035
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Lactate dehydrogenase (LDH) activity is elevated in many pathological states. Interest in LDH activity in sickle cell disease (SCD) has developed out of an increased comprehension of the pathophysiological process and the clinical course of the disease. Elevated LDH activity in SCD comes from various mechanisms, especially intravascular hemolysis, as well as ischemia-reperfusion damage and tissular necrosis. Intravascular hemolysis is associated with vasoconstriction, platelet activation, endothelial damage, and vascular complications. LDH has been used as a diagnostic and prognostic factor of acute and chronic complications. In this review we have evaluated the literature where LDH activity was examined during steady-state or acute conditions in SCD. (C) 2016 Elsevier B.V. All rights reserved.
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收藏
页码：99 / 102
页数：4
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